Cytotoxicity and inhibition of P-glycoprotein by selected medicinal plants from Thailand
Ethnopharmacological relevance - Thai medicine has a long tradition of tonifying medicinal plants. In the present investigation, we studied the flower extracts of Jasminum sambac, Mammea siamensis, Mesua ferrea, Michelia alba, Mimusops elengi, and Nelumbo nucifera and speculated that these plants mi...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
12 June 2014
|
| In: |
Journal of ethnopharmacology
Year: 2014, Jahrgang: 155, Heft: 1, Pages: 633-641 |
| ISSN: | 1872-7573 |
| DOI: | 10.1016/j.jep.2014.06.001 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jep.2014.06.001 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0378874114004358 
|
| Verfasserangaben: | Chanai Noysang, Anne Mahringer, Maen Zeino, Mohamed Saeed, Omboon Luanratana, Gert Fricker, Rudolf Bauer, Thomas Efferth |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 172778040X | ||
| 003 | DE-627 | ||
| 005 | 20230426130625.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200826s2014 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jep.2014.06.001 |2 doi | |
| 035 | |a (DE-627)172778040X | ||
| 035 | |a (DE-599)KXP172778040X | ||
| 035 | |a (OCoLC)1341357553 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Noysang, Chanai |e VerfasserIn |0 (DE-588)1216565139 |0 (DE-627)1727781368 |4 aut | |
| 245 | 1 | 0 | |a Cytotoxicity and inhibition of P-glycoprotein by selected medicinal plants from Thailand |c Chanai Noysang, Anne Mahringer, Maen Zeino, Mohamed Saeed, Omboon Luanratana, Gert Fricker, Rudolf Bauer, Thomas Efferth |
| 264 | 1 | |c 12 June 2014 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 26.08.2020 | ||
| 520 | |a Ethnopharmacological relevance - Thai medicine has a long tradition of tonifying medicinal plants. In the present investigation, we studied the flower extracts of Jasminum sambac, Mammea siamensis, Mesua ferrea, Michelia alba, Mimusops elengi, and Nelumbo nucifera and speculated that these plants might influence metabolism and substance flow in the body. - Materials and methods - Isolation of porcine brain capillary endothelial cells (PBCECs) as well as multidrug-resistance CEM/ADR5000 leukemia cells, MDA-M;B-231 breast cancer, U-251 brain tumor, and HCT-116 colon cancer cells were used. The calcein-acetoxymethylester (AM) assay was used to measure inhibition of P-glycoprotein transport. XTT and resazurin assays served for measuring cytotoxicity. - Results - The extracts revealed cytotoxicity towards CCRF-CEM leukemia cells to a different extent. The strongest growth inhibition was found for the n-hexane extracts of Mammea siamensis and Mesua ferrea, and the dichloromethane extracts of Mesua ferrea and Michelia alba. The flower extracts also inhibited P-glycoprotein function in porcine brain capillary endothelial cells and CEM/ADR5000 leukemia cells, indicating modulation of the blood-brain barrier and multidrug resistance of tumors. Bioactivity-guided isolation of coumarins from Mammea siamensis flowers revealed considerable cytotoxicity of mammea A/AA, deacetylmammea E/BA and deacetylmammea E/BB towards human MDA-MB-231 breast cancer, U-251 brain tumor, HCT-116 colon cancer, and CCRF-CEM leukemia cells. - Conclusion - The plants analyzed may be valuable in developing novel treatment strategies to overcome the blood-brain barrier and multidrug-resistance in tumor cells mediated by P-glycoprotein. | ||
| 650 | 4 | |a ABC transporter | |
| 650 | 4 | |a Blood-brain barrier | |
| 650 | 4 | |a Chemotherapy | |
| 650 | 4 | |a Herbal therapy | |
| 650 | 4 | |a Multidrug resistance | |
| 650 | 4 | |a Natural products | |
| 700 | 1 | |a Mahringer, Anne |e VerfasserIn |0 (DE-588)143168827 |0 (DE-627)704409607 |0 (DE-576)335452981 |4 aut | |
| 700 | 1 | |a Zeino, Maen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Saeed, Mohamed |e VerfasserIn |4 aut | |
| 700 | 1 | |a Luanratana, Omboon |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fricker, Gert |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bauer, Rudolf |e VerfasserIn |4 aut | |
| 700 | 1 | |a Efferth, Thomas |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of ethnopharmacology |d New York, NY [u.a.] : Elsevier, 1979 |g 155(2014), 1, Seite 633-641 |h Online-Ressource |w (DE-627)302467696 |w (DE-600)1491279-X |w (DE-576)081952767 |x 1872-7573 |7 nnas |a Cytotoxicity and inhibition of P-glycoprotein by selected medicinal plants from Thailand |
| 773 | 1 | 8 | |g volume:155 |g year:2014 |g number:1 |g pages:633-641 |g extent:9 |a Cytotoxicity and inhibition of P-glycoprotein by selected medicinal plants from Thailand |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.jep.2014.06.001 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S0378874114004358 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200826 | ||
| 993 | |a Article | ||
| 994 | |a 2014 | ||
| 998 | |g 143168827 |a Mahringer, Anne |m 143168827:Mahringer, Anne |d 160000 |d 160100 |e 160000PM143168827 |e 160100PM143168827 |k 0/160000/ |k 1/160000/160100/ |p 2 | ||
| 999 | |a KXP-PPN172778040X |e 3742738623 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"recId":"172778040X","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 26.08.2020"],"title":[{"title_sort":"Cytotoxicity and inhibition of P-glycoprotein by selected medicinal plants from Thailand","title":"Cytotoxicity and inhibition of P-glycoprotein by selected medicinal plants from Thailand"}],"person":[{"role":"aut","roleDisplay":"VerfasserIn","display":"Noysang, Chanai","given":"Chanai","family":"Noysang"},{"family":"Mahringer","given":"Anne","display":"Mahringer, Anne","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Zeino","given":"Maen","roleDisplay":"VerfasserIn","display":"Zeino, Maen","role":"aut"},{"given":"Mohamed","family":"Saeed","role":"aut","roleDisplay":"VerfasserIn","display":"Saeed, Mohamed"},{"family":"Luanratana","given":"Omboon","display":"Luanratana, Omboon","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Fricker","given":"Gert","display":"Fricker, Gert","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","display":"Bauer, Rudolf","roleDisplay":"VerfasserIn","given":"Rudolf","family":"Bauer"},{"family":"Efferth","given":"Thomas","roleDisplay":"VerfasserIn","display":"Efferth, Thomas","role":"aut"}],"relHost":[{"id":{"zdb":["1491279-X"],"eki":["302467696"],"issn":["1872-7573"]},"origin":[{"publisherPlace":"New York, NY [u.a.]","dateIssuedDisp":"1979-","dateIssuedKey":"1979","publisher":"Elsevier"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Journal of ethnopharmacology","subtitle":"an interdisciplinary journal devoted to bioscientific research on indigenous drugs ; the official journal of the International Society of Ethnopharmacology","title_sort":"Journal of ethnopharmacology"}],"recId":"302467696","corporate":[{"display":"International Society of Ethnopharmacology","roleDisplay":"Herausgebendes Organ","role":"isb"}],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Cytotoxicity and inhibition of P-glycoprotein by selected medicinal plants from ThailandJournal of ethnopharmacology","note":["Gesehen am 30.03.11"],"part":{"pages":"633-641","issue":"1","year":"2014","extent":"9","text":"155(2014), 1, Seite 633-641","volume":"155"},"pubHistory":["1.1979 -"]}],"physDesc":[{"extent":"9 S."}],"id":{"eki":["172778040X"],"doi":["10.1016/j.jep.2014.06.001"]},"origin":[{"dateIssuedKey":"2014","dateIssuedDisp":"12 June 2014"}],"name":{"displayForm":["Chanai Noysang, Anne Mahringer, Maen Zeino, Mohamed Saeed, Omboon Luanratana, Gert Fricker, Rudolf Bauer, Thomas Efferth"]}} | ||
| SRT | |a NOYSANGCHACYTOTOXICI1220 | ||