Quinapril treatment abolishes diabetes-associated atherosclerosis in RAGE/apolipoprotein E double knockout mice
Objective/Rationale - Both the renin-angiotensin system (RAS) and the receptor for advanced glycation end products (RAGE) potentiate diabetes-associated atherosclerosis (DAA). We assessed the effectiveness of concomitant RAS and RAGE inhibition on DAA. - Methods - Diabetic (5 × 55 mg/kg streptozotoc...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
4 June 2014
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| In: |
Atherosclerosis
Year: 2014, Jahrgang: 235, Heft: 2, Pages: 444-448 |
| ISSN: | 1879-1484 |
| DOI: | 10.1016/j.atherosclerosis.2014.05.945 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.atherosclerosis.2014.05.945 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0021915014012088 
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| Verfasserangaben: | Anna M.D. Watson, Jiaze Li, Dian Samijono, Angelika Bierhaus, Merlin C. Thomas, Karin A.M. Jandeleit-Dahm, Mark E. Cooper |
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| 245 | 1 | 0 | |a Quinapril treatment abolishes diabetes-associated atherosclerosis in RAGE/apolipoprotein E double knockout mice |c Anna M.D. Watson, Jiaze Li, Dian Samijono, Angelika Bierhaus, Merlin C. Thomas, Karin A.M. Jandeleit-Dahm, Mark E. Cooper |
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| 520 | |a Objective/Rationale - Both the renin-angiotensin system (RAS) and the receptor for advanced glycation end products (RAGE) potentiate diabetes-associated atherosclerosis (DAA). We assessed the effectiveness of concomitant RAS and RAGE inhibition on DAA. - Methods - Diabetic (5 × 55 mg/kg streptozotocin daily) and non-diabetic male RAGE/apolipoprotein E double knockout (RAGE/apoE DKO) mice were treated with quinapril (30 mg/kg/day) for 20 weeks. At the end of the study aortic plaques were assessed. - Results - Diabetic RAGE/apoE DKO showed significantly less plaque area than diabetic apoE KO mice. Plaque deposition was almost abolished in quinapril treated diabetic RAGE/apoE DKOs, with significant attenuation of vascular collagen deposition, nitrotyrosine staining, and reduced macrophage infiltration. Expression of the advanced glycation end product receptor 3 (galectin 3) was also significantly reduced. - Conclusion - Concomitant inhibition of RAS and RAGE signalling almost completely inhibited the development of experimental DAA. A dual therapeutic approach may be a superior strategy for the treatment of diabetic macrovascular disease.. | ||
| 650 | 4 | |a AGEs | |
| 650 | 4 | |a Atherosclerosis | |
| 650 | 4 | |a Experimental diabetes | |
| 650 | 4 | |a Mouse model | |
| 650 | 4 | |a RAGE | |
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