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Efficient and automated large-scale detection of structural relationships in proteins with a flexible aligner

The total number of known three-dimensional protein structures is rapidly increasing. Consequently, the need for fast structural search against complete databases without a significant loss of accuracy is increasingly demanding. Recently, TopSearch, an ultra-fast method for finding rigid structural...

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Bibliographische Detailangaben
Hauptverfasser: Gutiérrez, Fernando I. (VerfasserIn) , Rodriguez-Valenzuela, Felipe (VerfasserIn) , Ibarra, Ignacio L. (VerfasserIn) , Devos, Damien (VerfasserIn) , Melo, Francisco (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 05 January 2016
In: BMC bioinformatics
Year: 2016, Jahrgang: 17, Pages: 20
ISSN:1471-2105
DOI:10.1186/s12859-015-0866-8
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12859-015-0866-8
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Verfasserangaben:Fernando I. Gutiérrez, Felipe Rodriguez-Valenzuela, Ignacio L. Ibarra, Damien P. Devos and Francisco Melo
Beschreibung
Zusammenfassung:The total number of known three-dimensional protein structures is rapidly increasing. Consequently, the need for fast structural search against complete databases without a significant loss of accuracy is increasingly demanding. Recently, TopSearch, an ultra-fast method for finding rigid structural relationships between a query structure and the complete Protein Data Bank (PDB), at the multi-chain level, has been released. However, comparable accurate flexible structural aligners to perform efficient whole database searches of multi-domain proteins are not yet available. The availability of such a tool is critical for a sustainable boosting of biological discovery.
Beschreibung:Gesehen am 28.08.2020
Beschreibung:Online Resource
ISSN:1471-2105
DOI:10.1186/s12859-015-0866-8

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