Efficacy of nab-paclitaxel does not seem to be associated with SPARC expression in metastatic breast cancer
Aim: To evaluate the predictive value of the expression of the secreted protein acidic and rich in cysteine (SPARC) for nab-paclitaxel in metastatic breast cancer (MBC). Patients and Methods: Forty-four patients with progressive MBC were prospectively treated with nab-paclitaxel. Expression of SPARC...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
August 4, 2014
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| In: |
Anticancer research
Year: 2014, Jahrgang: 34, Heft: 11, Pages: 6609-6615 |
| ISSN: | 1791-7530 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: http://ar.iiarjournals.org/content/34/11/6609
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| Verfasserangaben: | Andreas Schneeweiss, Julia Seitz, Katharina Smetanay, Florian Schuetz, Dirk Jaeger, Andreas Bachinger, Markus Zorn, Hans-Peter Sinn and Frederik Marmé |
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| 245 | 1 | 0 | |a Efficacy of nab-paclitaxel does not seem to be associated with SPARC expression in metastatic breast cancer |c Andreas Schneeweiss, Julia Seitz, Katharina Smetanay, Florian Schuetz, Dirk Jaeger, Andreas Bachinger, Markus Zorn, Hans-Peter Sinn and Frederik Marmé |
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| 520 | |a Aim: To evaluate the predictive value of the expression of the secreted protein acidic and rich in cysteine (SPARC) for nab-paclitaxel in metastatic breast cancer (MBC). Patients and Methods: Forty-four patients with progressive MBC were prospectively treated with nab-paclitaxel. Expression of SPARC in tumor cells was assessed by an immunoreactive score, integrating staining intensity and percentage of positive tumor cells; expression in stroma based on staining intensity. SPARC serum levels were determined before 1st and 2nd cycle of nab-paclitaxel and at progression. By applying several cut-offs the association between SPARC expression or serum levels and clinical end-points was analyzed. Results: No clear association between expression of SPARC in primary or metastatic tumor tissue or in serum and any clinical end-point could be detected regardless of the various cut-offs applied. Conclusion: Efficacy of nab-paclitaxel in MBC does not seem to be associated with expression of SPARC in tumor tissues or serum. | ||
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