Influence of a positive family history of both type 2 diabetes and PCOS on metabolic and endocrine parameters in a large cohort of PCOS women
<section class="abstract"><div id="" class="section"><h3 class="abstractTitle text-title my-1" id="d5e3">Objective</h3><p>There is evidence suggesting a strong genetic background of polycystic ovary syndrome (PCOS). We a...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
May 2014
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| In: |
European journal of endocrinology
Year: 2014, Volume: 170, Issue: 5, Pages: 727-739 |
| ISSN: | 1479-683X |
| DOI: | 10.1530/EJE-13-1035 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1530/EJE-13-1035 Verlag, lizenzpflichtig, Volltext: https://eje.bioscientifica.com/view/journals/eje/170/5/727.xml 
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| Author Notes: | Elisabeth Lerchbaum, Verena Schwetz, Albrecht Giuliani and Barbara Obermayer-Pietsch |
| Summary: | <section class="abstract"><div id="" class="section"><h3 class="abstractTitle text-title my-1" id="d5e3">Objective</h3><p>There is evidence suggesting a strong genetic background of polycystic ovary syndrome (PCOS). We aim to study the metabolic and endocrine characteristics of PCOS women with and without a family history (FHx) of type 2 diabetes mellitus (T2DM) and PCOS.</p></div><div id="" class="section"><h3 class="abstractTitle text-title my-1" id="d5e6">Design</h3><p>Cross-sectional study.</p></div><div id="" class="section"><h3 class="abstractTitle text-title my-1" id="d5e9">Methods</h3><p>We analysed the association of T2DM FHx and PCOS FHx with metabolic and endocrine parameters in 714 PCOS women.</p></div><div id="" class="section"><h3 class="abstractTitle text-title my-1" id="d5e12">Results</h3><p>A positive FHx of T2DM and PCOS were prevalent in 36.8 and 21.4% of PCOS women respectively. We found an independent association of T2DM FHx with central fat accumulation, obesity, prediabetes, metabolic syndrome (MS), insulin resistance, low HDL and elevated blood pressure (<em>P</em><0.05 for all). PCOS FHx was independently associated with prediabetes (<em>P</em><0.05). We observed an independent association of PCOS FHx with clinical and biochemical hyperandrogenism (<em>P</em><0.05 for all), whereas there was no independent association of T2DM FHx with hyperandrogenism. PCOS women with a positive FHx of both T2DM and PCOS had an adverse metabolic and endocrine profile including a linear increase in risk of obesity, central fat accumulation, MS, prediabetes and low HDL (<em>P</em><0.05 for all).</p></div><div id="" class="section"><h3 class="abstractTitle text-title my-1" id="d5e24">Conclusions</h3><p>Our findings suggest that the assessment of FHx might allow risk stratification of PCOS women, which is important considering the high prevalence of PCOS.</p></div></section> |
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| Item Description: | Gesehen am 01.09.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1479-683X |
| DOI: | 10.1530/EJE-13-1035 |