Influence of a positive family history of both type 2 diabetes and PCOS on metabolic and endocrine parameters in a large cohort of PCOS women
<section class="abstract"><div id="" class="section"><h3 class="abstractTitle text-title my-1" id="d5e3">Objective</h3><p>There is evidence suggesting a strong genetic background of polycystic ovary syndrome (PCOS). We a...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
May 2014
|
| In: |
European journal of endocrinology
Year: 2014, Volume: 170, Issue: 5, Pages: 727-739 |
| ISSN: | 1479-683X |
| DOI: | 10.1530/EJE-13-1035 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1530/EJE-13-1035 Verlag, lizenzpflichtig, Volltext: https://eje.bioscientifica.com/view/journals/eje/170/5/727.xml 
|
| Author Notes: | Elisabeth Lerchbaum, Verena Schwetz, Albrecht Giuliani and Barbara Obermayer-Pietsch |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 172850371X | ||
| 003 | DE-627 | ||
| 005 | 20220818185745.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200901s2014 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1530/EJE-13-1035 |2 doi | |
| 035 | |a (DE-627)172850371X | ||
| 035 | |a (DE-599)KXP172850371X | ||
| 035 | |a (OCoLC)1341358027 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Lerchbaum, Elisabeth |e VerfasserIn |0 (DE-588)1068937459 |0 (DE-627)821074288 |0 (DE-576)428312543 |4 aut | |
| 245 | 1 | 0 | |a Influence of a positive family history of both type 2 diabetes and PCOS on metabolic and endocrine parameters in a large cohort of PCOS women |c Elisabeth Lerchbaum, Verena Schwetz, Albrecht Giuliani and Barbara Obermayer-Pietsch |
| 264 | 1 | |c May 2014 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 01.09.2020 | ||
| 520 | |a <section class="abstract"><div id="" class="section"><h3 class="abstractTitle text-title my-1" id="d5e3">Objective</h3><p>There is evidence suggesting a strong genetic background of polycystic ovary syndrome (PCOS). We aim to study the metabolic and endocrine characteristics of PCOS women with and without a family history (FHx) of type 2 diabetes mellitus (T2DM) and PCOS.</p></div><div id="" class="section"><h3 class="abstractTitle text-title my-1" id="d5e6">Design</h3><p>Cross-sectional study.</p></div><div id="" class="section"><h3 class="abstractTitle text-title my-1" id="d5e9">Methods</h3><p>We analysed the association of T2DM FHx and PCOS FHx with metabolic and endocrine parameters in 714 PCOS women.</p></div><div id="" class="section"><h3 class="abstractTitle text-title my-1" id="d5e12">Results</h3><p>A positive FHx of T2DM and PCOS were prevalent in 36.8 and 21.4% of PCOS women respectively. We found an independent association of T2DM FHx with central fat accumulation, obesity, prediabetes, metabolic syndrome (MS), insulin resistance, low HDL and elevated blood pressure (<em>P</em><0.05 for all). PCOS FHx was independently associated with prediabetes (<em>P</em><0.05). We observed an independent association of PCOS FHx with clinical and biochemical hyperandrogenism (<em>P</em><0.05 for all), whereas there was no independent association of T2DM FHx with hyperandrogenism. PCOS women with a positive FHx of both T2DM and PCOS had an adverse metabolic and endocrine profile including a linear increase in risk of obesity, central fat accumulation, MS, prediabetes and low HDL (<em>P</em><0.05 for all).</p></div><div id="" class="section"><h3 class="abstractTitle text-title my-1" id="d5e24">Conclusions</h3><p>Our findings suggest that the assessment of FHx might allow risk stratification of PCOS women, which is important considering the high prevalence of PCOS.</p></div></section> | ||
| 700 | 1 | |a Schwetz, Verena |e VerfasserIn |4 aut | |
| 700 | 1 | |a Giuliani, Albrecht |e VerfasserIn |4 aut | |
| 700 | 1 | |a Obermayer-Pietsch, Barbara |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of endocrinology |d Oxford : Oxford University Press, 1994 |g 170(2014), 5, Seite 727-739 |h Online-Ressource |w (DE-627)30151741X |w (DE-600)1485160-X |w (DE-576)079421466 |x 1479-683X |7 nnas |a Influence of a positive family history of both type 2 diabetes and PCOS on metabolic and endocrine parameters in a large cohort of PCOS women |
| 773 | 1 | 8 | |g volume:170 |g year:2014 |g number:5 |g pages:727-739 |g extent:13 |a Influence of a positive family history of both type 2 diabetes and PCOS on metabolic and endocrine parameters in a large cohort of PCOS women |
| 856 | 4 | 0 | |u https://doi.org/10.1530/EJE-13-1035 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://eje.bioscientifica.com/view/journals/eje/170/5/727.xml |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200901 | ||
| 993 | |a Article | ||
| 994 | |a 2014 | ||
| 998 | |g 1068937459 |a Lerchbaum, Elisabeth |m 1068937459:Lerchbaum, Elisabeth |p 1 |x j | ||
| 999 | |a KXP-PPN172850371X |e 3745757270 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Lerchbaum","given":"Elisabeth","roleDisplay":"VerfasserIn","display":"Lerchbaum, Elisabeth","role":"aut"},{"given":"Verena","family":"Schwetz","role":"aut","roleDisplay":"VerfasserIn","display":"Schwetz, Verena"},{"display":"Giuliani, Albrecht","roleDisplay":"VerfasserIn","role":"aut","family":"Giuliani","given":"Albrecht"},{"display":"Obermayer-Pietsch, Barbara","roleDisplay":"VerfasserIn","role":"aut","family":"Obermayer-Pietsch","given":"Barbara"}],"title":[{"title":"Influence of a positive family history of both type 2 diabetes and PCOS on metabolic and endocrine parameters in a large cohort of PCOS women","title_sort":"Influence of a positive family history of both type 2 diabetes and PCOS on metabolic and endocrine parameters in a large cohort of PCOS women"}],"recId":"172850371X","language":["eng"],"note":["Gesehen am 01.09.2020"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"name":{"displayForm":["Elisabeth Lerchbaum, Verena Schwetz, Albrecht Giuliani and Barbara Obermayer-Pietsch"]},"id":{"doi":["10.1530/EJE-13-1035"],"eki":["172850371X"]},"origin":[{"dateIssuedDisp":"May 2014","dateIssuedKey":"2014"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["30151741X"],"zdb":["1485160-X"],"issn":["1479-683X"]},"origin":[{"publisherPlace":"Oxford ; Bristol","dateIssuedDisp":"1994-","publisher":"Oxford University Press ; BioScientifica Ltd.","dateIssuedKey":"1994"}],"titleAlt":[{"title":"EJE"},{"title":"European journal of endocrinology"},{"title":"official journal of the European Federation of Endocrine Societies"},{"title":"EJE"}],"part":{"text":"170(2014), 5, Seite 727-739","volume":"170","extent":"13","year":"2014","pages":"727-739","issue":"5"},"pubHistory":["Volume 130, issue 1 (Jan 1994)-"],"language":["eng"],"recId":"30151741X","disp":"Influence of a positive family history of both type 2 diabetes and PCOS on metabolic and endocrine parameters in a large cohort of PCOS womenEuropean journal of endocrinology","note":["Gesehen am 21.08.25"],"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"subtitle":"EJE : clinical and translational endocrinology from around the globe","title":"European journal of endocrinology","title_sort":"European journal of endocrinology"}]}],"physDesc":[{"extent":"13 S."}]} | ||
| SRT | |a LERCHBAUMEINFLUENCEO2014 | ||