The assessment of Background Parenchymal Enhancement (BPE) in a high-risk population: what causes BPE?

OBJECTIVE: To investigate promoting factors for background parenchymal enhancement (BPE) in MR mammography (MRM). METHODS: 146 patients were retrospectively evaluated, including 91 high-risk patients (50 BRCA patients, 41 patients with elevated lifetime risk). 56 screening patients were matched to t...

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Main Authors: You, Chao (Author) , Krammer, Julia (Author) , Schönberg, Stefan (Author) , Kaiser, Clemens G. (Author)
Format: Article (Journal)
Language:English
Published: April 2018
In: Translational oncology
Year: 2018, Volume: 11, Issue: 2, Pages: 243-249
ISSN:1936-5233
DOI:10.1016/j.tranon.2017.12.006
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.tranon.2017.12.006
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1936523317303790
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Author Notes:Chao You, Anna K. Kaiser, Pascal Baltzer, Julia Krammer, Yajia Gu, Weijun Peng, Stefan O. Schönberg and Clemens G. Kaiser

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520 |a OBJECTIVE: To investigate promoting factors for background parenchymal enhancement (BPE) in MR mammography (MRM). METHODS: 146 patients were retrospectively evaluated, including 91 high-risk patients (50 BRCA patients, 41 patients with elevated lifetime risk). 56 screening patients were matched to the high-risk cases on the basis of age. The correlation of BPE with factors such as fibroglandular tissue (FGT), age, menopausal status, breast cancer, high-risk precondition as well as motion were investigated using linear regression. RESULTS: BPE positively correlated with FGT (P<.001) and negatively correlated with menopausal status (P<.001). Cancer did not show an effect on BPE (P>.05). A high-risk precondition showed a significant impact on the formation of BPE (P<.05). However, when corrected for motion, the correlation between BPE and a high-risk precondition became weak and insignificant, and a highly significant association between BPE and motion was revealed (P<.01). CONCLUSION: BPE positively correlated with FGT and negatively correlated with age. Cancer did not have an effect on BPE. A high-risk precondition appears to have a negative effect on BPE. However, when corrected for motion, high-risk preconditions became insignificant. Technical as well as physiological influences seem to play an important role in the formation of BPE. 
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