Mechanistic investigation of the nickel-catalyzed carbonylation of alcohols
The carbonylation of alcohols represents a straightforward and atom-efficient methodology for the preparation of carboxylic acids. It is desirable to perform these reactions under precious metal-free and low-pressure conditions, with regioselectivity control. In this work, we present a detailed mech...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 6, 2020
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| In: |
Organometallics
Year: 2020, Jahrgang: 39, Heft: 6, Pages: 870-880 |
| ISSN: | 1520-6041 |
| DOI: | 10.1021/acs.organomet.0c00082 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1021/acs.organomet.0c00082 Verlag, lizenzpflichtig, Volltext: https://pubs.acs.org/doi/10.1021/acs.organomet.0c00082 
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| Verfasserangaben: | Sara Sabater, Maximilian Menche, Tamal Ghosh, Saskia Krieg, Katharina S. L. Rück, Rocco Paciello, Ansgar Schäfer, Peter Comba, A. Stephen K. Hashmi, and Thomas Schaub |
| Zusammenfassung: | The carbonylation of alcohols represents a straightforward and atom-efficient methodology for the preparation of carboxylic acids. It is desirable to perform these reactions under precious metal-free and low-pressure conditions, with regioselectivity control. In this work, we present a detailed mechanistic study of a catalytic system based on NiI2, which can carbonylate benzylic alcohols in a highly regioselective manner to the corresponding branched carboxylic acids, core motifs for nonsteroidal drugs. |
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| Beschreibung: | Gesehen am 02.09.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 1520-6041 |
| DOI: | 10.1021/acs.organomet.0c00082 |