Matched unrelated donor allogeneic transplantation provides comparable long-term outcome to HLA-identical sibling transplantation in relapsed diffuse large B-cell lymphoma
The objective of this retrospective analysis was to compare outcomes of patients with diffuse large B-cell lymphoma (DLBCL) who received either a matched sibling (sib) or an unrelated donor (URD) allogeneic hematopoietic cell transplantation (allo-HCT). Long-term outcome of 172 DLBCL patients receiv...
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| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
10 February 2014
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| In: |
Bone marrow transplantation
Year: 2014, Volume: 49, Issue: 5, Pages: 671-678 |
| ISSN: | 1476-5365 |
| DOI: | 10.1038/bmt.2014.4 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/bmt.2014.4 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/bmt20144 
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| Author Notes: | I Avivi, C Canals, J-P Vernant, G Wulf, A Nagler, O Hermine, E Petersen, I Yakoub-Agha, C Craddock, A Schattenberg, D Niederwieser, K Thomson, D Blaise, M Attal, M Pfreundschuh, J Passweg, N Russell, P Dreger, A Sureda on behalf of the EBMT Lymphoma Working Party |
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| 245 | 1 | 0 | |a Matched unrelated donor allogeneic transplantation provides comparable long-term outcome to HLA-identical sibling transplantation in relapsed diffuse large B-cell lymphoma |c I Avivi, C Canals, J-P Vernant, G Wulf, A Nagler, O Hermine, E Petersen, I Yakoub-Agha, C Craddock, A Schattenberg, D Niederwieser, K Thomson, D Blaise, M Attal, M Pfreundschuh, J Passweg, N Russell, P Dreger, A Sureda on behalf of the EBMT Lymphoma Working Party |
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| 520 | |a The objective of this retrospective analysis was to compare outcomes of patients with diffuse large B-cell lymphoma (DLBCL) who received either a matched sibling (sib) or an unrelated donor (URD) allogeneic hematopoietic cell transplantation (allo-HCT). Long-term outcome of 172 DLBCL patients receiving URD-HCT between 2000 and 2007 and reported to the European Group for Blood and Marrow Transplantation, was compared with that of 301 subjects, allografted from sib-HCT. With a median follow-up of 45 months, 3-year PFS approached 35% for both groups; overall survival (OS) was 42% for sib-HCT versus 37% for URD (NS). Multivariate analyses confirmed that donor type was not associated with differences in non-relapse mortality (NRM), relapse rate (RR), PFS or OS. Poor performance status (PS) and refractory disease adversely affected PFS and OS. Prior auto-SCT and multiple previous therapies predicted for shorter PFS. NRM was adversely affected by older age (⩾50 years), poor PS and refractory disease, and RR by time from diagnosis to allo-HCT of <36 months, prior auto-SCT, refractory disease, poor PS and in vivo T-cell depletion with alemtuzumab. This large study shows for the first time that URD-HCT is not inferior to sib-HCT, providing a reasonable therapeutic approach for DLBCL patients, having no HLA-identical sibling available. | ||
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