In vitro testing of drug combinations employing nilotinib and alkylating agents with regard to pretransplant conditioning treatment of advanced-phase chronic myeloid leukemia
The prognosis of patients with advanced-phase chronic myeloid leukemia (CML) remains dismal despite the availability of targeted therapies and allogeneic stem cell transplantation (allo-SCT). Increasing the antileukemic efficacy of the pretransplant conditioning regimen may be a strategy to increase...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) Editorial |
| Sprache: | Englisch |
| Veröffentlicht: |
20 July 2014
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| In: |
Cancer chemotherapy and pharmacology
Year: 2014, Jahrgang: 74, Heft: 2, Pages: 427-432 |
| ISSN: | 1432-0843 |
| DOI: | 10.1007/s00280-014-2533-6 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00280-014-2533-6 Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007%2Fs00280-014-2533-6 
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| Verfasserangaben: | Aleksandar Radujkovic · Thomas Luft · Peter Dreger · Anthony D. Ho · W. Jens Zeller · Stefan Fruehauf · Julian Topaly |
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| 520 | |a The prognosis of patients with advanced-phase chronic myeloid leukemia (CML) remains dismal despite the availability of targeted therapies and allogeneic stem cell transplantation (allo-SCT). Increasing the antileukemic efficacy of the pretransplant conditioning regimen may be a strategy to increase remission rates and duration. We therefore investigated the antiproliferative effects of nilotinib in combination with drugs that are usually used for conditioning: the alkylating agents mafosfamide, treosulfan, and busulfan. | ||
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