Support and challenges to the melanosomal casing model based on nanoscale distribution of metals within iris melanosomes detected by X-ray fluorescence analysis
Melanin within melanosomes exists as eumelanin or pheomelanin. Distributions of these melanins have been studied extensively within tissues, but less often within individual melanosomes. Here, we apply X-ray fluorescence analysis with synchrotron radiation to survey the nanoscale distribution of met...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
5 June 2014
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| In: |
Pigment cell & melanoma research
Year: 2014, Volume: 27, Issue: 5, Pages: 831-834 |
| ISSN: | 1755-148X |
| DOI: | 10.1111/pcmr.12278 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/pcmr.12278 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/pcmr.12278 
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| Author Notes: | Thomas Gorniak, Tamás Haraszti, Heikki Suhonen, Yang Yang, Adam Hedberg‐Buenz, Demelza Koehn, Ruth Heine, Michael Grunze, Axel Rosenhahn and Michael G. Anderson |
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| 520 | |a Melanin within melanosomes exists as eumelanin or pheomelanin. Distributions of these melanins have been studied extensively within tissues, but less often within individual melanosomes. Here, we apply X-ray fluorescence analysis with synchrotron radiation to survey the nanoscale distribution of metals within purified melanosomes of mice. The study allows a discovery-based characterization of melanosomal metals, and, because Cu is specifically associated with eumelanin, a hypothesis-based test of the ‘casing model’ predicting that melanosomes contain a pheomelanin core surrounded by a eumelanin shell. Analysis of Cu, Ca, and Zn shows variable concentrations and distributions, with Ca/Zn highly correlated, and at least three discrete patterns for the distribution of Cu vs. Ca/Zn in different melanosomes - including one with a Cu-rich shell surrounding a Ca/Zn-rich core. Thus, the results support predictions of the casing model, but also suggest that in at least some tissues and genetic contexts, other arrangements of melanin may co-exist. | ||
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