New pancreatic cancer biomarkers eIF1, eIF2D, eIF3C and eIF6 play a major role in translational control in ductal Adenocarcinoma
Background/Aim: Pancreatic cancer is one of the deadliest forms of cancer and ranks among the leading causes of cancer-related death worldwide. The most common histological type is ductal adenocarcinoma (PDAC), accounting for approximately 95% of cases. Deregulation of protein synthesis has been fou...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
Jun 2020
|
| In: |
Anticancer research
Year: 2020, Jahrgang: 40, Heft: 6, Pages: 3109-3118 |
| ISSN: | 1791-7530 |
| DOI: | 10.21873/anticanres.14292 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.21873/anticanres.14292 Verlag, lizenzpflichtig, Volltext: http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.14292 
|
| Verfasserangaben: | Nicole Golob-Schwarzl, Philip Puchas, Margit Gogg-Kamerer, Wilko Weichert, Benjamin Göppert and Johannes Haybaeck |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1728972892 | ||
| 003 | DE-627 | ||
| 005 | 20220818192328.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200907s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.21873/anticanres.14292 |2 doi | |
| 035 | |a (DE-627)1728972892 | ||
| 035 | |a (DE-599)KXP1728972892 | ||
| 035 | |a (OCoLC)1341358851 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Golob-Schwarzl, Nicole |e VerfasserIn |0 (DE-588)1217211357 |0 (DE-627)1728973880 |4 aut | |
| 245 | 1 | 0 | |a New pancreatic cancer biomarkers eIF1, eIF2D, eIF3C and eIF6 play a major role in translational control in ductal Adenocarcinoma |c Nicole Golob-Schwarzl, Philip Puchas, Margit Gogg-Kamerer, Wilko Weichert, Benjamin Göppert and Johannes Haybaeck |
| 264 | 1 | |c Jun 2020 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 07.09.2020 | ||
| 520 | |a Background/Aim: Pancreatic cancer is one of the deadliest forms of cancer and ranks among the leading causes of cancer-related death worldwide. The most common histological type is ductal adenocarcinoma (PDAC), accounting for approximately 95% of cases. Deregulation of protein synthesis has been found to be closely related to cancer. The rate-limiting step of translation is initiation, which is regulated by a broad range of eukaryotic translation initiation factors (eIFs). Patients and Methods: Human PDAC samples were biochemically analyzed for the expression of various eIF subunits on the protein level (immunohistochemistry, immunoblot analyses) in 174 cases of PDAC in comparison with non-neoplastic pancreatic tissue (n=10). Results: Our investigation revealed a significant down-regulation of four specific eIF subunits, namely eIF1, eIF2D, eIF3C and eIF6. Concomitantly, the protein (immunoblot) levels of eIF1, eIF2D, eIF3C and eIF6 were reduced in PDAC samples as compared with non-neoplastic pancreatic tissue. Conclusion: Members of the eIF family are of relevance in pancreatic tumor biology and may play a major role in translational control in PDAC. | ||
| 700 | 1 | |a Puchas, Philip |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gogg-Kamerer, Margit |e VerfasserIn |4 aut | |
| 700 | 1 | |a Weichert, Wilko |e VerfasserIn |4 aut | |
| 700 | 1 | |a Goeppert, Benjamin |d 1977- |e VerfasserIn |0 (DE-588)1022581635 |0 (DE-627)717004244 |0 (DE-576)365641324 |4 aut | |
| 700 | 1 | |a Haybaeck, Johannes |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Anticancer research |d Kapandriti, Attiki, Greece : International Institute of Anticancer Research, 2004 |g 40(2020), 6, Seite 3109-3118 |h Online-Ressource |w (DE-627)387478493 |w (DE-600)2145376-7 |w (DE-576)358408717 |x 1791-7530 |7 nnas |a New pancreatic cancer biomarkers eIF1, eIF2D, eIF3C and eIF6 play a major role in translational control in ductal Adenocarcinoma |
| 773 | 1 | 8 | |g volume:40 |g year:2020 |g number:6 |g pages:3109-3118 |g extent:9 |a New pancreatic cancer biomarkers eIF1, eIF2D, eIF3C and eIF6 play a major role in translational control in ductal Adenocarcinoma |
| 856 | 4 | 0 | |u https://doi.org/10.21873/anticanres.14292 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://ar.iiarjournals.org/lookup/doi/10.21873/anticanres.14292 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200907 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 1022581635 |a Goeppert, Benjamin |m 1022581635:Goeppert, Benjamin |d 910000 |d 912000 |e 910000PG1022581635 |e 912000PG1022581635 |k 0/910000/ |k 1/910000/912000/ |p 5 | ||
| 999 | |a KXP-PPN1728972892 |e 3747348785 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"note":["Gesehen am 07.09.2020"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"Jun 2020","dateIssuedKey":"2020"}],"title":[{"title":"New pancreatic cancer biomarkers eIF1, eIF2D, eIF3C and eIF6 play a major role in translational control in ductal Adenocarcinoma","title_sort":"New pancreatic cancer biomarkers eIF1, eIF2D, eIF3C and eIF6 play a major role in translational control in ductal Adenocarcinoma"}],"person":[{"display":"Golob-Schwarzl, Nicole","family":"Golob-Schwarzl","role":"aut","given":"Nicole"},{"display":"Puchas, Philip","family":"Puchas","given":"Philip","role":"aut"},{"role":"aut","given":"Margit","family":"Gogg-Kamerer","display":"Gogg-Kamerer, Margit"},{"given":"Wilko","role":"aut","family":"Weichert","display":"Weichert, Wilko"},{"display":"Goeppert, Benjamin","family":"Goeppert","role":"aut","given":"Benjamin"},{"role":"aut","given":"Johannes","family":"Haybaeck","display":"Haybaeck, Johannes"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["International Institute of Anticancer Research"]},"recId":"387478493","pubHistory":["Nachgewiesen 24.2004 -"],"id":{"zdb":["2145376-7"],"eki":["387478493"],"issn":["1791-7530"]},"disp":"New pancreatic cancer biomarkers eIF1, eIF2D, eIF3C and eIF6 play a major role in translational control in ductal AdenocarcinomaAnticancer research","part":{"issue":"6","extent":"9","volume":"40","year":"2020","text":"40(2020), 6, Seite 3109-3118","pages":"3109-3118"},"note":["Gesehen am 26.02.13"],"origin":[{"dateIssuedDisp":"2004-","publisherPlace":"Kapandriti, Attiki, Greece","publisher":"International Institute of Anticancer Research","dateIssuedKey":"2004"}],"title":[{"subtitle":"international journal of cancer research and treatment","title_sort":"Anticancer research","title":"Anticancer research"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"]}],"id":{"eki":["1728972892"],"doi":["10.21873/anticanres.14292"]},"recId":"1728972892","name":{"displayForm":["Nicole Golob-Schwarzl, Philip Puchas, Margit Gogg-Kamerer, Wilko Weichert, Benjamin Göppert and Johannes Haybaeck"]},"physDesc":[{"extent":"9 S."}]} | ||
| SRT | |a GOLOBSCHWANEWPANCREA2020 | ||