Predictive value of longitudinal whole-body magnetic resonance imaging in patients with smoldering multiple myeloma
Previous studies demonstrated the relevance of focal lesions (FL) in whole-body magnetic resonance imaging (wb-MRI) at the initial workup of patients with smoldering multiple myeloma (SMM). The aim of this study was to assess the effects of longitudinal wb-MRIs on progression into multiple myeloma (...
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| Hauptverfasser: | , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
[2014]
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| In: |
Leukemia
Year: 2014, Jahrgang: 28, Heft: 9, Pages: 1902-1908 |
| ISSN: | 1476-5551 |
| DOI: | 10.1038/leu.2014.75 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/leu.2014.75 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/leu201475 
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| Verfasserangaben: | M. Merz, T. Hielscher, B. Wagner, S. Sauer, S. Shah, M. S. Raab, A. Jauch, K. Neben, D. Hose, G. Egerer, M.-A. Weber, S. Delorme, H. Goldschmidt, J. Hillengass |
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| 245 | 1 | 0 | |a Predictive value of longitudinal whole-body magnetic resonance imaging in patients with smoldering multiple myeloma |c M. Merz, T. Hielscher, B. Wagner, S. Sauer, S. Shah, M. S. Raab, A. Jauch, K. Neben, D. Hose, G. Egerer, M.-A. Weber, S. Delorme, H. Goldschmidt, J. Hillengass |
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| 520 | |a Previous studies demonstrated the relevance of focal lesions (FL) in whole-body magnetic resonance imaging (wb-MRI) at the initial workup of patients with smoldering multiple myeloma (SMM). The aim of this study was to assess the effects of longitudinal wb-MRIs on progression into multiple myeloma (MM). Sixty-three patients with SMM were analyzed who received at least two wb-MRIs for follow-up before progression into MM. Radiological progressive disease (MRI-PD) was defined as detection of new FL or increase in diameter of existing FL and a novel or progressive diffuse infiltration. Radiological stable disease (MRI-SD) was defined by no change compared with the prior MRI. Patients were followed-up every 3-6 months, including a serological and clinical evaluation. One Hundred and eighty-two wb-MRIs were analyzed. MRI-PD occurred in 31 patients (49%), and 25 (40%) patients developed MM. MRI-PD was highly significantly associated with progression into MM, regardless of findings at the initial MRI. In multivariate analysis, MRI-PD remained a risk factor, independent of relevant baseline parameters like serum monoclonal protein or ⩾95% aberrant plasma cells in the bone marrow. Patients with MRI-SD had no higher risk of progression, even when FL were present at the initial MRI. Therefore, MRI is suitable for the follow-up of patients with SMM. | ||
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