Tumor cell dissemination to the bone marrow and blood is associated with poor outcome in patients with metastatic breast cancer
The purpose of this study was to assess the impact of disseminated tumor cells (DTCs) on progression-free and overall survival (OS) in patients with metastatic breast cancer (MBC) and to compare it to simultaneous detection of circulating tumor cells (CTCs) from the blood in a subgroup. Disseminated...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
24. August 2014
|
| In: |
Breast cancer research and treatment
Year: 2014, Jahrgang: 147, Heft: 2, Pages: 345-351 |
| ISSN: | 1573-7217 |
| DOI: | 10.1007/s10549-014-3113-5 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s10549-014-3113-5
|
| Verfasserangaben: | Andreas D. Hartkopf, Diana Stefanescu, Markus Wallwiener, Markus Hahn, Sven Becker, Erich-Franz Solomayer, Tanja N. Fehm, Sara Y. Brucker, Florin-Andrei Taran |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1729844553 | ||
| 003 | DE-627 | ||
| 005 | 20240406193253.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200910s2014 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10549-014-3113-5 |2 doi | |
| 035 | |a (DE-627)1729844553 | ||
| 035 | |a (DE-599)KXP1729844553 | ||
| 035 | |a (OCoLC)1341359273 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hartkopf, Andreas |d 1979- |e VerfasserIn |0 (DE-588)139124101 |0 (DE-627)703216279 |0 (DE-576)309901596 |4 aut | |
| 245 | 1 | 0 | |a Tumor cell dissemination to the bone marrow and blood is associated with poor outcome in patients with metastatic breast cancer |c Andreas D. Hartkopf, Diana Stefanescu, Markus Wallwiener, Markus Hahn, Sven Becker, Erich-Franz Solomayer, Tanja N. Fehm, Sara Y. Brucker, Florin-Andrei Taran |
| 264 | 1 | |c 24. August 2014 | |
| 300 | |b Diagramme | ||
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 10.09.2020 | ||
| 520 | |a The purpose of this study was to assess the impact of disseminated tumor cells (DTCs) on progression-free and overall survival (OS) in patients with metastatic breast cancer (MBC) and to compare it to simultaneous detection of circulating tumor cells (CTCs) from the blood in a subgroup. Disseminated tumor cells were identified in bone marrow (BM) aspirates by immunocytochemistry (pancytokeratin antibody A45-B/B3) and cytomorphology prior to the beginning of a new-line therapy. CTCs were enumerated by the CellSearch® technology. BM was obtained from 178 patients with MBC; 64/178 (36 %) patients were DTC-positive. Disseminated tumor cells occurred more frequently in patients with visceral metastases (p = 0.020) and ≥2 lines of therapy (p = 0.017). CTCs were assessed in 33 of these patients and 17/33 (52 %) patients had CTC counts ≥5 CTCs/7.5 ml blood. There was no significant association between the DTC and CTC status. Univariate analysis revealed DTC detection as a significant predictor of poor OS (p < 0.001); median OS in DTC-negative versus DTC-positive patients was 52 [95 % confidence interval (CI) 38-67] versus 28 [95 % CI 19-37] months. Moreover, as described previously, patients with ≥5 CTCs/7.5 ml blood were at an increased risk of disease progression (p = 0.026) and death (p = 0.025). Disseminated tumor cells are predictors of poor prognosis in MBC, highlighting the role of tumor cell dissemination into the BM for breast cancer progression. The absence of a significant association between concurrent DTCs and CTCs suggests they might represent different aspects of systemic BC spread. | ||
| 700 | 1 | |a Stefanescu, Diana |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wallwiener, Markus |d 1980- |e VerfasserIn |0 (DE-588)134044827 |0 (DE-627)692043934 |0 (DE-576)27468327X |4 aut | |
| 700 | 1 | |a Hahn, Markus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Becker, Sven |e VerfasserIn |4 aut | |
| 700 | 1 | |a Solomayer, Erich-Franz |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fehm, Tanja N. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brucker, Sara Y. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Taran, Florin-Andrei |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Breast cancer research and treatment |d Dordrecht [u.a.] : Springer Science + Business Media B.V., 1981 |g 147(2014), 2, Seite 345-351 |h Online-Ressource |w (DE-627)320433722 |w (DE-600)2004077-5 |w (DE-576)104194162 |x 1573-7217 |7 nnas |a Tumor cell dissemination to the bone marrow and blood is associated with poor outcome in patients with metastatic breast cancer |
| 773 | 1 | 8 | |g volume:147 |g year:2014 |g number:2 |g pages:345-351 |g extent:7 |a Tumor cell dissemination to the bone marrow and blood is associated with poor outcome in patients with metastatic breast cancer |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s10549-014-3113-5 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200910 | ||
| 993 | |a Article | ||
| 994 | |a 2014 | ||
| 998 | |g 134044827 |a Wallwiener, Markus |m 134044827:Wallwiener, Markus |d 910000 |d 910400 |d 50000 |e 910000PW134044827 |e 910400PW134044827 |e 50000PW134044827 |k 0/910000/ |k 1/910000/910400/ |k 0/50000/ |p 3 | ||
| 999 | |a KXP-PPN1729844553 |e 3748876688 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"disp":"Tumor cell dissemination to the bone marrow and blood is associated with poor outcome in patients with metastatic breast cancerBreast cancer research and treatment","type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"year":"2014","volume":"147","issue":"2","extent":"7","pages":"345-351","text":"147(2014), 2, Seite 345-351"},"language":["eng"],"pubHistory":["1.1981 -"],"note":["Gesehen am 02.12.05","Fortsetzung der Druck-Ausgabe"],"id":{"issn":["1573-7217"],"eki":["320433722"],"zdb":["2004077-5"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Breast cancer research and treatment","title_sort":"Breast cancer research and treatment"}],"origin":[{"dateIssuedDisp":"1981-","publisher":"Springer Science + Business Media B.V. ; Kluwer","publisherPlace":"Dordrecht [u.a.] ; Dordrecht [u.a.]","dateIssuedKey":"1981"}],"recId":"320433722"}],"origin":[{"dateIssuedKey":"2014","dateIssuedDisp":"24. August 2014"}],"title":[{"title_sort":"Tumor cell dissemination to the bone marrow and blood is associated with poor outcome in patients with metastatic breast cancer","title":"Tumor cell dissemination to the bone marrow and blood is associated with poor outcome in patients with metastatic breast cancer"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"physDesc":[{"extent":"7 S.","noteIll":"Diagramme"}],"id":{"doi":["10.1007/s10549-014-3113-5"],"eki":["1729844553"]},"recId":"1729844553","person":[{"display":"Hartkopf, Andreas","given":"Andreas","role":"aut","family":"Hartkopf"},{"family":"Stefanescu","role":"aut","display":"Stefanescu, Diana","given":"Diana"},{"given":"Markus","display":"Wallwiener, Markus","family":"Wallwiener","role":"aut"},{"family":"Hahn","role":"aut","given":"Markus","display":"Hahn, Markus"},{"display":"Becker, Sven","given":"Sven","family":"Becker","role":"aut"},{"display":"Solomayer, Erich-Franz","given":"Erich-Franz","role":"aut","family":"Solomayer"},{"given":"Tanja N.","display":"Fehm, Tanja N.","family":"Fehm","role":"aut"},{"role":"aut","family":"Brucker","given":"Sara Y.","display":"Brucker, Sara Y."},{"role":"aut","family":"Taran","display":"Taran, Florin-Andrei","given":"Florin-Andrei"}],"note":["Gesehen am 10.09.2020"],"language":["eng"],"name":{"displayForm":["Andreas D. Hartkopf, Diana Stefanescu, Markus Wallwiener, Markus Hahn, Sven Becker, Erich-Franz Solomayer, Tanja N. Fehm, Sara Y. Brucker, Florin-Andrei Taran"]}} | ||
| SRT | |a HARTKOPFANTUMORCELLD2420 | ||