Analysis of IDH mutation, 1p/19q deletion, and PTEN loss delineates prognosis in clinical low-grade diffuse gliomas
Background: Grades II and III gliomas have unpredictable rates of progression, making management decisions difficult. Currently, several clinical and radiological characteristics are utilized to predict progression and survival but collectively are suboptimal. Methods: In this study, we analyzed a s...
Gespeichert in:
| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
26 January 2014
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| In: |
Neuro-Oncology
Year: 2014, Jahrgang: 16, Heft: 7, Pages: 914-923 |
| ISSN: | 1523-5866 |
| DOI: | 10.1093/neuonc/not299 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/neuonc/not299 Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/neuro-oncology/article/16/7/914/1437220 
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| Verfasserangaben: | Nesrin Sabha, Christiane B. Knobbe, Majula Maganti, Soha Al Omar, Mark Bernstein, Rob Cairns, Besmira Çako, Andreas von Deimling, David Capper, Tak W. Mak, Tim-Rasmus Kiehl, Philippe Carvalho, Evelyn Garrett, Arie Perry, Gelareh Zadeh, Abhijit Guha, and Sidney Croul |
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| 245 | 1 | 0 | |a Analysis of IDH mutation, 1p/19q deletion, and PTEN loss delineates prognosis in clinical low-grade diffuse gliomas |c Nesrin Sabha, Christiane B. Knobbe, Majula Maganti, Soha Al Omar, Mark Bernstein, Rob Cairns, Besmira Çako, Andreas von Deimling, David Capper, Tak W. Mak, Tim-Rasmus Kiehl, Philippe Carvalho, Evelyn Garrett, Arie Perry, Gelareh Zadeh, Abhijit Guha, and Sidney Croul |
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| 520 | |a Background: Grades II and III gliomas have unpredictable rates of progression, making management decisions difficult. Currently, several clinical and radiological characteristics are utilized to predict progression and survival but collectively are suboptimal. Methods: In this study, we analyzed a set of 108 nonenhancing hemispheric grade II–III gliomas. Demographic variables, including patient age, tumor diameter, extent of resection, and performance status, were combined with molecular data (IDH mutation status [mIDH], 1p/19q codeletion, PTEN deletion, and EGFR amplification). A complete dataset for all variables was compiled for 70 of the 108 patients. Both univariable and multivariable analyses were performed to determine whether the molecular data singly or in combination offer advantages over tumor type and grade for prediction of overall survival (OS) and/or progression-free rate (PFR). Results: Patient age, clinical variables (tumor diameter, extent of resection, performance status), and pathology (tumor type and grade) were not predictive of OS or PFR. IDH mutation status alone was predictive of longer OS and PFR for the entire group of tumors; 1p/19q deletion alone was predictive of OS but not PFR. In the multivariable analysis, none of the clinical or demographic factors were predictive of OS or PFR. IDH mutation status, 1p/19q codeletion, and PTEN deletion were predictive of OS (P = .003, P = .005, P = .02, respectively). Both mIDH (P < .001) and the interaction term of 1p/19q and PTEN (P < .001) were found to be predictive of PFR. Conclusions: We conclude that the combination of mIDH, 1p/19q codeletion, and PTEN deletion may be particularly effective in discriminating good prognosis from poor prognosis hemispheric gliomas. We propose that such a scheme merits testing on larger prospective cohorts. Should our findings be confirmed, routine clinical analysis of hemispheric gliomas for mIDH, 1p/19q codeletion, and PTEN deletion would be justified. | ||
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