SNP rs6564851 in the BCO1 gene is associated with varying provitamin A plasma concentrations but not with retinol concentrations among adolescents from rural Ghana
In sub-Saharan Africa, vitamin A deficiency constitutes a severe health problem despite various supplementation and food fortification programs. Given that the intake of preformed vitamin A from animal products remains low in these countries, an efficient metabolization of plant-based provitamin A c...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
16 June 2020
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| In: |
Nutrients
Year: 2020, Jahrgang: 12, Heft: 6 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu12061786 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/nu12061786 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2072-6643/12/6/1786 
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| Verfasserangaben: | Sophie Graßmann, Olga Pivovarova-Ramich, Andrea Henze, Jens Raila, Yaw Ampem Amoako, Richard King Nyamekye, George Bedu-Addo, Frank P. Mockenhaupt, Matthias B. Schulze and Ina Danquah |
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| 245 | 1 | 0 | |a SNP rs6564851 in the BCO1 gene is associated with varying provitamin A plasma concentrations but not with retinol concentrations among adolescents from rural Ghana |c Sophie Graßmann, Olga Pivovarova-Ramich, Andrea Henze, Jens Raila, Yaw Ampem Amoako, Richard King Nyamekye, George Bedu-Addo, Frank P. Mockenhaupt, Matthias B. Schulze and Ina Danquah |
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| 520 | |a In sub-Saharan Africa, vitamin A deficiency constitutes a severe health problem despite various supplementation and food fortification programs. Given that the intake of preformed vitamin A from animal products remains low in these countries, an efficient metabolization of plant-based provitamin A carotenoids is essential. Previously, adolescents in rural Ghana have shown high total plasma carotenoid concentrations, while 36% had a vitamin A deficiency (defined as plasma retinol < 0.7 µmol/L). Hence, the aim of this cross-sectional study was to identify the relationships between variants in the β-carotene 15,15’-oxygenase (BCO1) gene and plasma carotenoid concentrations among 189 15-year-old girls and boys in rural Ghana. BCO1 rs6564851, rs7500996, rs10048138 and PKD1L2 rs6420424, and rs8044334 were typed, and carotenoid concentrations were compared among the different genotypes. G allele carriers of rs6564851 (53%) showed higher plasma carotenoid concentrations than T allele carriers (median (interquartile range): 3.07 (2.17-4.02) vs. 2.59 (2.21-3.50) µmol/L, p-value = 0.0424). This was not explained by differences in socio-demographic or dietary factors. In contrast, no differences in plasma retinol concentrations were observed between these genotypes. Pending verification in independent populations, the low conversion efficiency of provitamin A carotenoids among rs6564851 G allele carriers may undermine existing fortification and supplementation programs to improve the vitamin A status in sub-Saharan Africa. | ||
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