Second allo-SCT in patients with lymphoma relapse after a first allogeneic transplantation. A retrospective study of the EBMT Lymphoma Working Party
The aim of this registry-based retrospective study was to analyze the outcome of second allogeneic hematopoietic SCT (alloHSCT_2) performed in patients with lymphoma who had relapsed after a first allogeneic transplant (alloHSCT_1). Patients ⩾18 years who had received an alloHSCT_2 for lymphoma rela...
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
9 March 2015
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| In: |
Bone marrow transplantation
Year: 2015, Jahrgang: 50, Heft: 6, Pages: 790-794 |
| ISSN: | 1476-5365 |
| DOI: | 10.1038/bmt.2015.12 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/bmt.2015.12 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/bmt201512 
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| Verfasserangaben: | K. Horstmann, A. Boumendil, J. Finke, H. Finel, E. Kanfer, G. Milone, N. Russell, A. Bacigalupo, Y. Chalandon, J.L. Diez-Martin, N. Ifrah, M. Jurado Chacon, P. Dreger |
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| 245 | 1 | 0 | |a Second allo-SCT in patients with lymphoma relapse after a first allogeneic transplantation. A retrospective study of the EBMT Lymphoma Working Party |c K. Horstmann, A. Boumendil, J. Finke, H. Finel, E. Kanfer, G. Milone, N. Russell, A. Bacigalupo, Y. Chalandon, J.L. Diez-Martin, N. Ifrah, M. Jurado Chacon, P. Dreger |
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| 520 | |a The aim of this registry-based retrospective study was to analyze the outcome of second allogeneic hematopoietic SCT (alloHSCT_2) performed in patients with lymphoma who had relapsed after a first allogeneic transplant (alloHSCT_1). Patients ⩾18 years who had received an alloHSCT_2 for lymphoma relapse between 2000 and 2011 were eligible. One hundred and forty patients were identified. The diagnosis was Hodgkin lymphoma (HL) in 31%, diffuse large B-cell lymphoma in 14%, T-cell lymphoma in 12%, indolent lymphoma in 19%, mantle cell lymphoma in 16% and other lymphomas in 8% of the patients. The median interval from alloHSCT_1 to alloHSCT_2 was 19 (range 4-116) months. Disease status at alloHSCT_2 was chemosensitive in 46%, refractory in 43% and unknown in 11% of the patients. Three-year PFS, OS, relapse incidence and nonrelapse mortality were 19%, 29%, 58% and 23%, respectively. PFS and OS were significantly affected by refractory disease at alloHSCT_2 and a short interval between alloHSCT_1 and alloHSCT_2. Long-term PFS was observed across all lymphoma subsets except for aggressive B-cell lymphoma. In conclusion, alloHSCT_2 is feasible and can result in long-term disease control in patients with lymphoma recurrence after alloHSCT_1, in particular if relapse occurs late and is chemosensitive. | ||
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| 700 | 1 | |a Finke, J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Finel, H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kanfer, E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Milone, G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Russell, N. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bacigalupo, A. |e VerfasserIn |4 aut | |
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