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Low-Level Laser therapy improves vision in a patient with retinitis pigmentosa

Objective: This case report describes the effects of low-level laser therapy (LLLT) in a single patient with retinitis pigmentosa (RP). Background data: RP is a heritable disorder of the retina, which eventually leads to blindness. No therapy is currently available. Methods: LLLT was applied using a...

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Bibliographic Details
Main Authors: Ivandic, Boris (Author) , Ivandić, Tomislav (Author)
Format: Article (Journal)
Language:English
Published: 12 Mar 2014
In: Photomedicine and laser surgery
Year: 2014, Volume: 32, Issue: 3, Pages: 181-184
ISSN:1557-8550
DOI:10.1089/pho.2013.3535
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1089/pho.2013.3535
Verlag, lizenzpflichtig, Volltext: https://www.liebertpub.com/doi/10.1089/pho.2013.3535
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Author Notes:Boris T. Ivandic, Tomislav Ivandic

MARC

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520 |a Objective: This case report describes the effects of low-level laser therapy (LLLT) in a single patient with retinitis pigmentosa (RP). Background data: RP is a heritable disorder of the retina, which eventually leads to blindness. No therapy is currently available. Methods: LLLT was applied using a continuous wave laser diode (780 nm, 10 mW average output at 292 Hz, 50% pulse modulation). The complete retina of eyes was irradiated through the conjunctiva for 40 sec (0.4 J, 0.333 W/cm2) two times per week for 2 weeks (1.6 J). A 55-year-old male patient with advanced RP was treated and followed for 7 years. Results: The patient had complained of nyctalopia and decreasing vision. At first presentation, best visual acuity was 20/50 in each eye. Visual fields were reduced to a central residual of 5 degrees. Tritan-dyschromatopsy was found. Retinal potential was absent in electroretinography. Biomicroscopy showed optic nerve atrophy, and narrow retinal vessels with a typical pattern of retinal pigmentation. After four initial treatments of LLLT, visual acuity increased to 20/20 in each eye. Visual fields normalized except for a mid-peripheral absolute concentric scotoma. Five years after discontinuation of LLLT, a relapse was observed. LLLT was repeated (another four treatments) and restored the initial success. During the next 2 years, 17 additional treatments were performed on an “as needed” basis, to maintain the result. Conclusions: LLLT was shown to improve and maintain vision in a patient with RP, and may thereby have contributed to slowing down blindness. 
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