GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3

Neuroblastoma is an embryonic solid tumor of neural crest origin and accounts for 11% of all cancer-related deaths in children. Novel therapeutic strategies are therefore urgently required. MYCN oncogene amplification, which occurs in 20% of neuroblastomas, is a hallmark of high risk. Here, we aimed...

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Main Authors:	Fabian, Johannes (Author) , Lodrini, Marco (Author) , Oehme, Ina (Author) , Schier, Marie Catherine (Author) , Thole, Theresa Maria (Author) , Hielscher, Thomas (Author) , Kopp-Schneider, Annette (Author) , Opitz, Lennart (Author) , Capper, David (Author) , Deimling, Andreas von (Author) , Rettig, Inga Edeltraud (Author) , Milde, Till (Author) , Mahlknecht, Ulrich Rudolph (Author) , Westermann, Frank (Author) , Popanda, Odilia (Author) , Roels, Frederik (Author) , Hero, Barbara (Author) , Berthold, Frank (Author) , Fischer, Matthias (Author) , Kulozik, Andreas (Author) , Witt, Olaf (Author) , Deubzer, Hedwig (Author)
Format:	Article (Journal)
Language:	English
Published:	January 13, 2014
In:	Cancer research Year: 2014, Volume: 74, Issue: 9, Pages: 2604-2616
ISSN:	1538-7445
DOI:	10.1158/0008-5472.CAN-13-1904
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1158/0008-5472.CAN-13-1904 Verlag, lizenzpflichtig, Volltext: https://cancerres.aacrjournals.org/content/74/9/2604
Author Notes:	Johannes Fabian, Marco Lodrini, Ina Oehme, Marie C. Schier, Theresa M. Thole, Thomas Hielscher, Annette Kopp-Schneider, Lennart Opitz, David Capper, Andreas von Deimling, Inga Wiegand, Till Milde, Ulrich Mahlknecht, Frank Westermann, Odilia Popanda, Frederik Roels, Barbara Hero, Frank Berthold, Matthias Fischer, Andreas E. Kulozik, Olaf Witt, and Hedwig E. Deubzer