Inhibition of IGF-I-related intracellular signaling pathways by proinflammatory cytokines in growth plate chondrocytes

Children with chronic inflammatory diseases suffer from severe growth failure associated with resistance toward the anabolic action of insulin-like growth factor I (IGF-I). We hypothesized that proinflammatory cytokines interfere with IGF-I signaling.

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Bibliographische Detailangaben
Hauptverfasser: Choukair, Daniela (VerfasserIn) , Hügel, Ulrike (VerfasserIn) , Sander, Anja (VerfasserIn) , Uhlmann, Lorenz (VerfasserIn) , Tönshoff, Burkhard (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: [September 2014]
In: Pediatric research
Year: 2014, Jahrgang: 76, Heft: 3, Pages: 245-251
ISSN:1530-0447
DOI:10.1038/pr.2014.84
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/pr.2014.84
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/pr201484
Volltext
Verfasserangaben:Daniela Choukair, Ulrike Hügel, Anja Sander, Lorenz Uhlmann and Burkhard Tönshoff
Beschreibung
Zusammenfassung:Children with chronic inflammatory diseases suffer from severe growth failure associated with resistance toward the anabolic action of insulin-like growth factor I (IGF-I). We hypothesized that proinflammatory cytokines interfere with IGF-I signaling.
Beschreibung:Avance online publication 16 July 2014
Gesehen am 18.09.2020
Beschreibung:Online Resource
ISSN:1530-0447
DOI:10.1038/pr.2014.84