BRAF V600E expression and distribution in desmoplastic infantile astrocytoma/ganglioglioma
Desmoplastic infantile astrocytoma/ganglioglioma (DIA/DIG) is a rare primary neuroepithelial brain tumour typically affecting paediatric patients younger than 24 months. Knowledge about genetic alterations in DIA/DIG is limited. However, a previous study on BRAF V600E mutation in paediatric glioma r...
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| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2014
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| In: |
Neuropathology & applied neurobiology
Year: 2014, Volume: 40, Issue: 3, Pages: 337-344 |
| ISSN: | 1365-2990 |
| DOI: | 10.1111/nan.12072 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1111/nan.12072 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/nan.12072 |
| Author Notes: | C. Koelsche, F. Sahm, W. Paulus, M. Mittelbronn, F. Giangaspero, M. Antonelli, J. Meyer, F. Lasitschka, A. von Deimling and D. Reuss |
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| 520 | |a Desmoplastic infantile astrocytoma/ganglioglioma (DIA/DIG) is a rare primary neuroepithelial brain tumour typically affecting paediatric patients younger than 24 months. Knowledge about genetic alterations in DIA/DIG is limited. However, a previous study on BRAF V600E mutation in paediatric glioma revealed a BRAF mutation in one of two tested DIAs/DIGs. The limited number of cases in that study did not allow any conclusion about mutation frequency of BRAF in this tumour entity. | ||
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