Age-specific sequence of colorectal cancer screening options in Germany: A model-based critical evaluation
Background The current organized screening program for colorectal cancer in Germany offers both sexes 5 annual fecal immunochemical tests (FITs) between ages 50 and 54 years, followed by a first screening colonoscopy at age 55 years if all of these FITs were negative. We sought to assess the implica...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
July 17, 2020
|
| In: |
PLoS medicine
Year: 2020, Volume: 17, Issue: 7 |
| ISSN: | 1549-1676 |
| DOI: | 10.1371/journal.pmed.1003194 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1371/journal.pmed.1003194 Verlag, Volltext: https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003194 
|
| Author Notes: | Thomas Heisser, Korbinian Weigl, Michael Hoffmeister, Hermann Brenner |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1733510613 | ||
| 003 | DE-627 | ||
| 005 | 20230427150658.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200921s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1371/journal.pmed.1003194 |2 doi | |
| 035 | |a (DE-627)1733510613 | ||
| 035 | |a (DE-599)KXP1733510613 | ||
| 035 | |a (OCoLC)1341360903 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Heisser, Thomas |d 1989- |e VerfasserIn |0 (DE-588)1201682207 |0 (DE-627)1685769683 |4 aut | |
| 245 | 1 | 0 | |a Age-specific sequence of colorectal cancer screening options in Germany |b A model-based critical evaluation |c Thomas Heisser, Korbinian Weigl, Michael Hoffmeister, Hermann Brenner |
| 264 | 1 | |c July 17, 2020 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.09.2020 | ||
| 520 | |a Background The current organized screening program for colorectal cancer in Germany offers both sexes 5 annual fecal immunochemical tests (FITs) between ages 50 and 54 years, followed by a first screening colonoscopy at age 55 years if all of these FITs were negative. We sought to assess the implications of this approach for key parameters of diagnostic performance. Methods and findings Using a multistate Markov model, we estimated the expected detection rates of advanced neoplasms (advanced adenomas and cancers) and number needed to scope (NNS) to detect 1 advanced neoplasm at a first screening colonoscopy conducted at age 55 after 5 preceding negative FITs and compared them with the corresponding estimates for a first screening colonoscopy at age 55 with no preceding FIT testing. In individuals with 5 consecutive negative FITs undergoing screening colonoscopy at age 55, expected colonoscopy detection rate (NNS) was 3.7% (27) and 0.10% (1,021) for any advanced neoplasm and cancer, respectively, in men, and 2.1% (47) and 0.05% (1,880) for any advanced neoplasm and cancer, respectively, in women. These NNS values for detecting 1 advanced neoplasm are approximately 3-fold higher, and the NNS values for detecting 1 cancer are approximately 8-fold higher, than those for a first screening colonoscopy at age 55 without prior FITs. This study is limited by model simplifying assumptions and uncertainties related to input parameters. Conclusions Screening colonoscopy at age 55 after 5 consecutive negative FITs at ages 50-54, as currently offered in the German cancer early detection program, is expected to have very low positive predictive value. Our results may inform efforts to enhance the design of screening programs. | ||
| 650 | 4 | |a Adenomas | |
| 650 | 4 | |a Cancer detection and diagnosis | |
| 650 | 4 | |a Cancer screening | |
| 650 | 4 | |a Colonoscopy | |
| 650 | 4 | |a Colorectal cancer | |
| 650 | 4 | |a German people | |
| 650 | 4 | |a Invasive tumors | |
| 650 | 4 | |a Malignant tumors | |
| 700 | 1 | |a Weigl, Korbinian |e VerfasserIn |0 (DE-588)1151338893 |0 (DE-627)1011574144 |0 (DE-576)477573959 |4 aut | |
| 700 | 1 | |a Hoffmeister, Michael |d 1973- |e VerfasserIn |0 (DE-588)134103726 |0 (DE-627)560880820 |0 (DE-576)277089565 |4 aut | |
| 700 | 1 | |a Brenner, Hermann |e VerfasserIn |0 (DE-588)1020516445 |0 (DE-627)691247005 |0 (DE-576)360642136 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a Public Library of Science |t PLoS medicine |d Lawrence, Kan. : PLoS, 2004 |g 17(2020,7) Artikel-Nummer e1003194, 13 Seiten |h Online-Ressource |w (DE-627)470151471 |w (DE-600)2164823-2 |w (DE-576)273890131 |x 1549-1676 |7 nnas |
| 773 | 1 | 8 | |g volume:17 |g year:2020 |g number:7 |g extent:13 |a Age-specific sequence of colorectal cancer screening options in Germany A model-based critical evaluation |
| 856 | 4 | 0 | |u https://doi.org/10.1371/journal.pmed.1003194 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003194 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200921 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 1020516445 |a Brenner, Hermann |m 1020516445:Brenner, Hermann |d 50000 |d 850000 |d 851600 |e 50000PB1020516445 |e 850000PB1020516445 |e 851600PB1020516445 |k 0/50000/ |k 0/850000/ |k 1/850000/851600/ |p 4 |y j | ||
| 998 | |g 134103726 |a Hoffmeister, Michael |m 134103726:Hoffmeister, Michael |d 50000 |e 50000PH134103726 |k 0/50000/ |p 3 | ||
| 998 | |g 1151338893 |a Weigl, Korbinian |m 1151338893:Weigl, Korbinian |d 50000 |e 50000PW1151338893 |k 0/50000/ |p 2 | ||
| 998 | |g 1201682207 |a Heisser, Thomas |m 1201682207:Heisser, Thomas |d 50000 |e 50000PH1201682207 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1733510613 |e 3759940528 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2020","dateIssuedDisp":"July 17, 2020"}],"note":["Gesehen am 21.09.2020"],"physDesc":[{"extent":"13 S."}],"title":[{"title":"Age-specific sequence of colorectal cancer screening options in Germany","title_sort":"Age-specific sequence of colorectal cancer screening options in Germany","subtitle":"A model-based critical evaluation"}],"person":[{"role":"aut","display":"Heisser, Thomas","given":"Thomas","family":"Heisser"},{"given":"Korbinian","family":"Weigl","display":"Weigl, Korbinian","role":"aut"},{"role":"aut","display":"Hoffmeister, Michael","given":"Michael","family":"Hoffmeister"},{"display":"Brenner, Hermann","role":"aut","family":"Brenner","given":"Hermann"}],"relHost":[{"pubHistory":["1.2004 -"],"id":{"zdb":["2164823-2"],"issn":["1549-1676"],"eki":["470151471"]},"recId":"470151471","name":{"displayForm":["Public Library of Science"]},"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedKey":"2004","publisherPlace":"Lawrence, Kan.","publisher":"PLoS","dateIssuedDisp":"2004-"}],"note":["Fortsetzung der Druck-Ausgabe","Gesehen am 20.11.2020"],"disp":"Public Library of SciencePLoS medicine","type":{"bibl":"periodical","media":"Online-Ressource"},"titleAlt":[{"title":"Medicine"}],"language":["eng"],"part":{"issue":"7","text":"17(2020,7) Artikel-Nummer e1003194, 13 Seiten","extent":"13","volume":"17","year":"2020"},"corporate":[{"display":"Public Library of Science","role":"aut"}],"title":[{"title_sort":"PLoS medicine","title":"PLoS medicine"}]}],"language":["eng"],"name":{"displayForm":["Thomas Heisser, Korbinian Weigl, Michael Hoffmeister, Hermann Brenner"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"1733510613","id":{"doi":["10.1371/journal.pmed.1003194"],"eki":["1733510613"]}} | ||
| SRT | |a HEISSERTHOAGESPECIFI1720 | ||