Frequency of therapy-relevant staging shifts in colorectal cancer through the introduction of pN1c in the 7th TNM edition
Background - pN1c is a novel N-category introduced for colorectal cancer (CRC) in current TNM (Tumour, Node, Metastasis) classification. It represents cancers displaying tumour deposits (TDs) in the fat but no involvement of lymph nodes. pN1c is integrated into the UICC (International Union Against...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
30 September 2014
|
| In: |
European journal of cancer
Year: 2014, Jahrgang: 50, Heft: 17, Pages: 2958-2965 |
| ISSN: | 1879-0852 |
| DOI: | 10.1016/j.ejca.2014.09.002 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejca.2014.09.002 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S095980491400937X 
|
| Verfasserangaben: | M. von Winterfeld, M. Hoffmeister, B. Ingold-Heppner, L. Jansen, S. Tao, E. Herpel, P. Schirmacher, M. Dietel, J. Chang-Claude, F. Autschbach, H. Brenner, H. Bläker |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1733526862 | ||
| 003 | DE-627 | ||
| 005 | 20220818203416.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200922s2014 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ejca.2014.09.002 |2 doi | |
| 035 | |a (DE-627)1733526862 | ||
| 035 | |a (DE-599)KXP1733526862 | ||
| 035 | |a (OCoLC)1341360897 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Winterfeld, Moritz von |d 1983- |e VerfasserIn |0 (DE-588)14349287X |0 (DE-627)70450698X |0 (DE-576)337359423 |4 aut | |
| 245 | 1 | 0 | |a Frequency of therapy-relevant staging shifts in colorectal cancer through the introduction of pN1c in the 7th TNM edition |c M. von Winterfeld, M. Hoffmeister, B. Ingold-Heppner, L. Jansen, S. Tao, E. Herpel, P. Schirmacher, M. Dietel, J. Chang-Claude, F. Autschbach, H. Brenner, H. Bläker |
| 264 | 1 | |c 30 September 2014 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 22.09.2020 | ||
| 520 | |a Background - pN1c is a novel N-category introduced for colorectal cancer (CRC) in current TNM (Tumour, Node, Metastasis) classification. It represents cancers displaying tumour deposits (TDs) in the fat but no involvement of lymph nodes. pN1c is integrated into the UICC (International Union Against Cancer) staging system and shifts previous stage II cancers (6th edition) to stage III. We investigated the frequency of upstaging and TD prognostic significance. - Methods - 414 CRCs, consecutively collected during a population-based epidemiological study, TNM classified and UICC staged according to the 6th TNM edition were reinvestigated for TD presence. The association with survival was investigated after a median follow-up time of 5years in multivariate analyses among nodal negative and positive cases. - Results - TDs were found in 103 (24.9%) cancers and were strongly associated with T-, N- and M-stages (p<0.0001, each). Upstaging of previous stage II cancers by the presence of TDs (pN1c) was found in six of 140 cases (4.3% of stage II, 1.4% of all tumours). For stage III CRC, strongly reduced overall, CRC-specific and recurrence-free survival were observed with the presence of TDs (hazard ratios (HR) 2.29, 95% confidence interval 1.27-4.10, HR 2.51, 1.27-4.98, and HR 2.43, 1.32-4.48, respectively). - Conclusions - Upstaging of CRCs through the introduction of pN1c occurs in less than 5% of previous stage II and less than 2% of all cancers. Given the biologic relevance of TDs, integration into the UICC staging relevant N-category is justified. The high prognostic impact of TDs, however, is not reflected in nodal positive cancers in both the TNM and UICC staging systems. | ||
| 650 | 4 | |a Colorectal cancer | |
| 650 | 4 | |a pN1c | |
| 650 | 4 | |a Tumour deposits | |
| 700 | 1 | |a Herpel, Esther |d 1973- |e VerfasserIn |0 (DE-588)12965227X |0 (DE-627)476593662 |0 (DE-576)297767984 |4 aut | |
| 700 | 1 | |a Schirmacher, Peter |d 1961- |e VerfasserIn |0 (DE-588)1020440112 |0 (DE-627)691221197 |0 (DE-576)360427448 |4 aut | |
| 700 | 1 | |a Bläker, Hendrik |d 1969- |e VerfasserIn |0 (DE-588)12093860X |0 (DE-627)08098150X |0 (DE-576)292457324 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of cancer |d Amsterdam [u.a.] : Elsevier, 1992 |g 50(2014), 17, Seite 2958-2965 |w (DE-627)266883400 |w (DE-600)1468190-0 |w (DE-576)090954173 |x 1879-0852 |7 nnas |a Frequency of therapy-relevant staging shifts in colorectal cancer through the introduction of pN1c in the 7th TNM edition |
| 773 | 1 | 8 | |g volume:50 |g year:2014 |g number:17 |g pages:2958-2965 |g extent:8 |a Frequency of therapy-relevant staging shifts in colorectal cancer through the introduction of pN1c in the 7th TNM edition |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ejca.2014.09.002 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S095980491400937X |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200922 | ||
| 993 | |a Article | ||
| 998 | |g 12093860X |a Bläker, Hendrik |m 12093860X:Bläker, Hendrik |d 910000 |d 912000 |e 910000PB12093860X |e 912000PB12093860X |k 0/910000/ |k 1/910000/912000/ |p 12 |y j | ||
| 998 | |g 1020440112 |a Schirmacher, Peter |m 1020440112:Schirmacher, Peter |d 910000 |d 912000 |e 910000PS1020440112 |e 912000PS1020440112 |k 0/910000/ |k 1/910000/912000/ |p 7 | ||
| 998 | |g 12965227X |a Herpel, Esther |m 12965227X:Herpel, Esther |d 910000 |d 912000 |e 910000PH12965227X |e 912000PH12965227X |k 0/910000/ |k 1/910000/912000/ |p 6 | ||
| 999 | |a KXP-PPN1733526862 |e 3759983995 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["M. von Winterfeld, M. Hoffmeister, B. Ingold-Heppner, L. Jansen, S. Tao, E. Herpel, P. Schirmacher, M. Dietel, J. Chang-Claude, F. Autschbach, H. Brenner, H. Bläker"]},"recId":"1733526862","note":["Gesehen am 22.09.2020"],"physDesc":[{"extent":"8 S."}],"person":[{"role":"aut","display":"Winterfeld, Moritz von","family":"Winterfeld","given":"Moritz von"},{"given":"Esther","display":"Herpel, Esther","family":"Herpel","role":"aut"},{"role":"aut","display":"Schirmacher, Peter","family":"Schirmacher","given":"Peter"},{"display":"Bläker, Hendrik","family":"Bläker","given":"Hendrik","role":"aut"}],"title":[{"title_sort":"Frequency of therapy-relevant staging shifts in colorectal cancer through the introduction of pN1c in the 7th TNM edition","title":"Frequency of therapy-relevant staging shifts in colorectal cancer through the introduction of pN1c in the 7th TNM edition"}],"relHost":[{"disp":"Frequency of therapy-relevant staging shifts in colorectal cancer through the introduction of pN1c in the 7th TNM editionEuropean journal of cancer","recId":"266883400","pubHistory":["28.1992 -"],"note":["Gesehen am 21.03.24","Ungezählte Beil.: Supplement"],"type":{"media":"Online-Ressource","bibl":"periodical"},"corporate":[{"display":"European Organization for Research on Treatment of Cancer","role":"isb"},{"role":"isb","display":"European Association for Cancer Research"},{"role":"isb","display":"European School of Oncology"}],"language":["eng"],"id":{"eki":["266883400"],"zdb":["1468190-0"],"issn":["1879-0852"]},"origin":[{"publisherPlace":"Amsterdam [u.a.] ; [Erscheinungsort nicht ermittelbar]","dateIssuedDisp":"1992-","publisher":"Elsevier ; Pergamon Press","dateIssuedKey":"1992"}],"part":{"volume":"50","pages":"2958-2965","text":"50(2014), 17, Seite 2958-2965","year":"2014","extent":"8","issue":"17"},"title":[{"title_sort":"European journal of cancer","title":"European journal of cancer"}],"titleAlt":[{"title":"EJC online"}]}],"id":{"eki":["1733526862"],"doi":["10.1016/j.ejca.2014.09.002"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"origin":[{"dateIssuedDisp":"30 September 2014","dateIssuedKey":"2014"}]} | ||
| SRT | |a WINTERFELDFREQUENCYO3020 | ||