Buchumschlag

A mechanochemical model for rho GTPase mediated cell polarization

Directed motility of eukaryotic cells requires the polarization of the actomyosin cytoskeleton. In many cell types the polar alignment of the actomyosin cytoskeleton occurs in response to a front-rear symmetry break of active Rho GTPase. Experimental evidence in neutrophils indicates that membrane t...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Kopfer, Kai H. (VerfasserIn) , Jäger, Willi (VerfasserIn) , Matthäus, Franziska (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 9 July 2020
In: Journal of theoretical biology
Year: 2020, Jahrgang: 504
ISSN:1095-8541
DOI:10.1016/j.jtbi.2020.110386
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jtbi.2020.110386
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0022519320302411
Volltext
Verfasserangaben:Kai H. Kopfer, Willi Jäger, Franziska Matthäus

MARC

LEADER 00000caa a2200000 c 4500
001 1733571752
003 DE-627
005 20220818204100.0
007 cr uuu---uuuuu
008 200922s2020 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.jtbi.2020.110386  |2 doi 
035 |a (DE-627)1733571752 
035 |a (DE-599)KXP1733571752 
035 |a (OCoLC)1341361246 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 27  |2 sdnb 
100 1 |a Kopfer, Kai H.  |d 1983-  |e VerfasserIn  |0 (DE-588)1027213820  |0 (DE-627)728607093  |0 (DE-576)372619428  |4 aut 
245 1 2 |a A mechanochemical model for rho GTPase mediated cell polarization  |c Kai H. Kopfer, Willi Jäger, Franziska Matthäus 
264 1 |c 9 July 2020 
300 |a 13 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 22.09.2020 
520 |a Directed motility of eukaryotic cells requires the polarization of the actomyosin cytoskeleton. In many cell types the polar alignment of the actomyosin cytoskeleton occurs in response to a front-rear symmetry break of active Rho GTPase. Experimental evidence in neutrophils indicates that membrane tension plays an important role in the confinement of active Rac to the front domain. We suggest a mechanochemical model for polarization, including Rho GTPase mediated actomyosin cytoskeleton dynamics and changes in membrane tension as an upstream controller of Rho GTP that reflects this observation. The model comprises the Rho GTPases Rac and RhoA which can become activated in response to external signals. The active states regulate the actomyosin mechanics. The model cell is considered as a thin, effectively two dimensional, sheet adhering to a flat substrate. Morphological changes of the actomyosin cytoskeleton induce changes in membrane tension. We numerically show that the model exhibits key features of neutrophil polarization. The model accounts for a simple mechanochemical circuit with the ability to generate robust polarity patterns, wherein cell mechanics serve as a long range signal transmitter. 
650 4 |a Mechanochemical model 
650 4 |a Neutrophil migration 
650 4 |a Polarization 
650 4 |a Tension 
650 4 |a Wave pinning 
700 1 |a Jäger, Willi  |d 1940-  |e VerfasserIn  |0 (DE-588)132750783  |0 (DE-627)526873094  |0 (DE-576)161561349  |4 aut 
700 1 |a Matthäus, Franziska  |d 1975-  |e VerfasserIn  |0 (DE-588)1053291493  |0 (DE-627)789749823  |0 (DE-576)409030031  |4 aut 
773 0 8 |i Enthalten in  |t Journal of theoretical biology  |d Amsterdam : Elsevier Ltd., 1961  |g 504(2020) Artikel-Nummer 110386, 13 Seiten  |h Online-Ressource  |w (DE-627)267838204  |w (DE-600)1470953-3  |w (DE-576)104344636  |x 1095-8541  |7 nnas  |a A mechanochemical model for rho GTPase mediated cell polarization 
773 1 8 |g volume:504  |g year:2020  |g extent:13  |a A mechanochemical model for rho GTPase mediated cell polarization 
856 4 0 |u https://doi.org/10.1016/j.jtbi.2020.110386  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u http://www.sciencedirect.com/science/article/pii/S0022519320302411  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20200922 
993 |a Article 
994 |a 2020 
998 |g 132750783  |a Jäger, Willi  |m 132750783:Jäger, Willi  |d 110000  |d 110200  |d 110000  |d 110400  |d 700000  |d 708000  |e 110000PJ132750783  |e 110200PJ132750783  |e 110000PJ132750783  |e 110400PJ132750783  |e 700000PJ132750783  |e 708000PJ132750783  |k 0/110000/  |k 1/110000/110200/  |k 0/110000/  |k 1/110000/110400/  |k 0/700000/  |k 1/700000/708000/  |p 2 
999 |a KXP-PPN1733571752  |e 3760411061 
BIB |a Y 
SER |a journal 
JSO |a {"physDesc":[{"extent":"13 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["1470953-3"],"eki":["267838204"],"issn":["1095-8541"]},"origin":[{"publisherPlace":"Amsterdam ; London [u.a.]","dateIssuedKey":"1961","publisher":"Elsevier Ltd. ; Academic Press","dateIssuedDisp":"1961-"}],"recId":"267838204","language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 22.09.2021"],"disp":"A mechanochemical model for rho GTPase mediated cell polarizationJournal of theoretical biology","part":{"extent":"13","text":"504(2020) Artikel-Nummer 110386, 13 Seiten","volume":"504","year":"2020"},"pubHistory":["1.1961 - 267.2010; Vol. 268.2011 -"],"title":[{"title":"Journal of theoretical biology","title_sort":"Journal of theoretical biology"}]}],"origin":[{"dateIssuedKey":"2020","dateIssuedDisp":"9 July 2020"}],"id":{"doi":["10.1016/j.jtbi.2020.110386"],"eki":["1733571752"]},"name":{"displayForm":["Kai H. Kopfer, Willi Jäger, Franziska Matthäus"]},"note":["Gesehen am 22.09.2020"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"1733571752","language":["eng"],"title":[{"title":"A mechanochemical model for rho GTPase mediated cell polarization","title_sort":"mechanochemical model for rho GTPase mediated cell polarization"}],"person":[{"roleDisplay":"VerfasserIn","display":"Kopfer, Kai H.","role":"aut","family":"Kopfer","given":"Kai H."},{"display":"Jäger, Willi","roleDisplay":"VerfasserIn","role":"aut","family":"Jäger","given":"Willi"},{"display":"Matthäus, Franziska","roleDisplay":"VerfasserIn","role":"aut","family":"Matthäus","given":"Franziska"}]} 
SRT |a KOPFERKAIHMECHANOCHE9202 

Ähnliche Einträge