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Sources of individual variability: miRNAs that predispose to neuropathic pain identified using genome-wide sequencing

We carried out a genome-wide study, using microRNA sequencing (miRNA-seq), aimed at identifying miRNAs in primary sensory neurons that are associated with neuropathic pain. Such scans usually yield long lists of transcripts regulated by nerve injury, but not necessarily related to pain. To overcome...

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Bibliographische Detailangaben
Hauptverfasser: Bali, Kiran Kumar (VerfasserIn) , Hackenberg, Michael (VerfasserIn) , Lubin, Avigail (VerfasserIn) , Kuner, Rohini (VerfasserIn) , Devor, Marshall (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 19 March 2014
In: Molecular pain
Year: 2014, Jahrgang: 10
ISSN:1744-8069
DOI:10.1186/1744-8069-10-22
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1186/1744-8069-10-22
Verlag, lizenzpflichtig, Volltext: https://journals.sagepub.com/doi/10.1186/1744-8069-10-22
Volltext
Verfasserangaben:Kiran Kumar Bali, Michael Hackenberg, Avigail Lubin, Rohini Kuner and Marshall Devor
Beschreibung
Zusammenfassung:We carried out a genome-wide study, using microRNA sequencing (miRNA-seq), aimed at identifying miRNAs in primary sensory neurons that are associated with neuropathic pain. Such scans usually yield long lists of transcripts regulated by nerve injury, but not necessarily related to pain. To overcome this we tried a novel search strategy: identification of transcripts regulated differentially by nerve injury in rat lines very similar except for a contrasting pain phenotype. Dorsal root ganglia (DRGs) L4 and 5 in the two lines were excised 3 days after spinal nerve ligation surgery (SNL) and small RNAs were extracted and sequenced.
Beschreibung:Article first published online: January 1, 2014
Gesehen am 22.09.2020
Beschreibung:Online Resource
ISSN:1744-8069
DOI:10.1186/1744-8069-10-22

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