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Exponential signaling gain at the receptor level enhances signal-to-noise ratio in bacterial chemotaxis

Cellular signaling systems show astonishing precision in their response to external stimuli despite strong fluctuations in the molecular components that determine pathway activity. To control the effects of noise on signaling most efficiently, living cells employ compensatory mechanisms that reach f...

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Bibliographic Details
Main Authors: Neumann-Pfeifer, Silke (Author) , Løvdok, Linda (Author) , Bentele, Kajetan (Author) , Meisig, Johannes (Author) , Ullner, Ekkehard (Author) , Paldy, Ferencz S. (Author) , Sourjik, Victor (Author) , Kollmann, Markus (Author)
Format: Article (Journal)
Language:English
Published: April 15, 2014
In: PLOS ONE
Year: 2014, Volume: 9, Issue: 4
ISSN:1932-6203
DOI:10.1371/journal.pone.0087815
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.pone.0087815
Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087815
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Author Notes:Silke Neumann, Linda Løvdok, Kajetan Bentele, Johannes Meisig, Ekkehard Ullner, Ferencz S. Paldy, Victor Sourjik, Markus Kollmann
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Summary:Cellular signaling systems show astonishing precision in their response to external stimuli despite strong fluctuations in the molecular components that determine pathway activity. To control the effects of noise on signaling most efficiently, living cells employ compensatory mechanisms that reach from simple negative feedback loops to robustly designed signaling architectures. Here, we report on a novel control mechanism that allows living cells to keep precision in their signaling characteristics - stationary pathway output, response amplitude, and relaxation time - in the presence of strong intracellular perturbations.
Item Description:Gesehen am 23.09.2020
Physical Description:Online Resource
ISSN:1932-6203
DOI:10.1371/journal.pone.0087815

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