Candida albicans uses the surface protein Gpm1 to attach to human endothelial cells and to keratinocytes via the adhesive protein vitronectin
Candida albicans is a major cause of invasive fungal infections worldwide. Upon infection and when in contact with human plasma as well as body fluids the fungus is challenged by the activated complement system a central part of the human innate immune response. C. albicans controls and evades host...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 13, 2014
|
| In: |
PLOS ONE
Year: 2014, Jahrgang: 9, Heft: 3 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0090796 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.pone.0090796 Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090796 
|
| Verfasserangaben: | Crisanto M. Lopez, Reinhard Wallich, Kristian Riesbeck, Christine Skerka, Peter F. Zipfel |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 173363472X | ||
| 003 | DE-627 | ||
| 005 | 20230426163440.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200923s2014 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1371/journal.pone.0090796 |2 doi | |
| 035 | |a (DE-627)173363472X | ||
| 035 | |a (DE-599)KXP173363472X | ||
| 035 | |a (OCoLC)1341361250 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Lopez, Crisanto M. |d 1979- |e VerfasserIn |0 (DE-588)1042517975 |0 (DE-627)769078362 |0 (DE-576)394001842 |4 aut | |
| 245 | 1 | 0 | |a Candida albicans uses the surface protein Gpm1 to attach to human endothelial cells and to keratinocytes via the adhesive protein vitronectin |c Crisanto M. Lopez, Reinhard Wallich, Kristian Riesbeck, Christine Skerka, Peter F. Zipfel |
| 264 | 1 | |c March 13, 2014 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 23.09.2020 | ||
| 520 | |a Candida albicans is a major cause of invasive fungal infections worldwide. Upon infection and when in contact with human plasma as well as body fluids the fungus is challenged by the activated complement system a central part of the human innate immune response. C. albicans controls and evades host complement attack by binding several human complement regulators like Factor H, Factor H-like protein 1 and C4BP to the surface. Gpm1 (Phosphoglycerate mutase 1) is one fungal Factor H/FHL1 -binding protein. As Gpm1 is surface exposed, we asked whether Gpm1 also contributes to host cell attachment. Here, we show by flow cytometry and by laser scanning microscopy that candida Gpm1 binds to human umbilical vein endothelial cells (HUVEC) to keratinocytes (HaCaT), and also to monocytic U937 cells. | ||
| 650 | 4 | |a Candida albicans | |
| 650 | 4 | |a Complement system | |
| 650 | 4 | |a Endothelial cells | |
| 650 | 4 | |a Extracellular matrix proteins | |
| 650 | 4 | |a Flow cytometry | |
| 650 | 4 | |a Fungal pathogens | |
| 650 | 4 | |a Immune serum | |
| 650 | 4 | |a Keratinocytes | |
| 700 | 1 | |a Wallich, Reinhard |e VerfasserIn |0 (DE-588)1059566710 |0 (DE-627)798640839 |0 (DE-576)163467781 |4 aut | |
| 700 | 1 | |a Riesbeck, Kristian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Skerka, Christine |e VerfasserIn |0 (DE-588)1216431868 |0 (DE-627)1727665090 |0 (DE-576)502821655 |4 aut | |
| 700 | 1 | |a Zipfel, Peter F. |d 1954- |e VerfasserIn |0 (DE-588)110935810 |0 (DE-627)691099006 |0 (DE-576)289687810 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t PLOS ONE |d San Francisco, California, US : PLOS, 2006 |g 9(2014,3) Artikel-Nummer e90796, 10 Seiten |h Online-Ressource |w (DE-627)523574592 |w (DE-600)2267670-3 |w (DE-576)281331979 |x 1932-6203 |7 nnas |a Candida albicans uses the surface protein Gpm1 to attach to human endothelial cells and to keratinocytes via the adhesive protein vitronectin |
| 773 | 1 | 8 | |g volume:9 |g year:2014 |g number:3 |a Candida albicans uses the surface protein Gpm1 to attach to human endothelial cells and to keratinocytes via the adhesive protein vitronectin |
| 856 | 4 | 0 | |u https://doi.org/10.1371/journal.pone.0090796 |x Resolving-System |x Verlag |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0090796 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200923 | ||
| 993 | |a Article | ||
| 994 | |a 2014 | ||
| 998 | |g 1059566710 |a Wallich, Reinhard |m 1059566710:Wallich, Reinhard |d 910000 |d 911600 |e 910000PW1059566710 |e 911600PW1059566710 |k 0/910000/ |k 1/910000/911600/ |p 2 | ||
| 999 | |a KXP-PPN173363472X |e 3760607322 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 23.09.2020"],"recId":"173363472X","relHost":[{"origin":[{"publisher":"PLOS ; PLoS","dateIssuedKey":"2006","dateIssuedDisp":"2006-","publisherPlace":"San Francisco, California, US ; Lawrence, Kan."}],"id":{"issn":["1932-6203"],"eki":["523574592"],"zdb":["2267670-3"]},"name":{"displayForm":["Public Library of Science"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"PLOS ONE","title_sort":"PLOS ONE"}],"pubHistory":["1.2006 -"],"part":{"issue":"3","year":"2014","volume":"9","text":"9(2014,3) Artikel-Nummer e90796, 10 Seiten"},"disp":"Candida albicans uses the surface protein Gpm1 to attach to human endothelial cells and to keratinocytes via the adhesive protein vitronectinPLOS ONE","note":["Schreibweise des Titels bis 2012: PLoS ONE","Gesehen am 20.03.19"],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"523574592","corporate":[{"display":"Public Library of Science","roleDisplay":"Herausgebendes Organ","role":"isb"}],"language":["eng"]}],"language":["eng"],"person":[{"roleDisplay":"VerfasserIn","display":"Lopez, Crisanto M.","role":"aut","family":"Lopez","given":"Crisanto M."},{"role":"aut","roleDisplay":"VerfasserIn","display":"Wallich, Reinhard","given":"Reinhard","family":"Wallich"},{"given":"Kristian","family":"Riesbeck","role":"aut","display":"Riesbeck, Kristian","roleDisplay":"VerfasserIn"},{"given":"Christine","family":"Skerka","role":"aut","roleDisplay":"VerfasserIn","display":"Skerka, Christine"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Zipfel, Peter F.","given":"Peter F.","family":"Zipfel"}],"name":{"displayForm":["Crisanto M. Lopez, Reinhard Wallich, Kristian Riesbeck, Christine Skerka, Peter F. Zipfel"]},"title":[{"title":"Candida albicans uses the surface protein Gpm1 to attach to human endothelial cells and to keratinocytes via the adhesive protein vitronectin","title_sort":"Candida albicans uses the surface protein Gpm1 to attach to human endothelial cells and to keratinocytes via the adhesive protein vitronectin"}],"origin":[{"dateIssuedDisp":"March 13, 2014","dateIssuedKey":"2014"}],"id":{"doi":["10.1371/journal.pone.0090796"],"eki":["173363472X"]}} | ||
| SRT | |a LOPEZCRISACANDIDAALB1320 | ||