Association of country-specific socioeconomic factors with survival of patients who experience severe classic acute graft-vs.-host disease after allogeneic hematopoietic cell transplantation: an analysis from the transplant complications working party of the EBMT
Acute graft-versus-host disease (aGvHD) is one of the most frequent causes of transplant-related mortality (TRM) after allogeneic hematopoietic cell transplantation (alloHCT). Its treatment is complex and costly. The aim of this study was to retrospectively analyze the impact of country-specific soc...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
23 July 2020
|
| In: |
Frontiers in immunology
Year: 2020, Jahrgang: 11 |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2020.01537 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3389/fimmu.2020.01537 Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2020.01537/full 
|
| Verfasserangaben: | Andrzej Frankiewicz, Christophe Peczynski, Sebastian Giebel, Alenca Harrington, Gerard Socié, Dietger Niederwieser, Christoph Scheid, Martin Bornhäuser, Nicolaus Kröger, Ahmet Elmaagacli, Boris Afanasyev, Peter Dreger, Claudia Rössig, Didier Blaise, Christian Kratz, Ibrahim Yakoub-Agha, Bernhard Kremens, Charlotte Marie Niemeyer, Gerald Wulf, Igor Blau, Olaf Penack, Hildegard Greinix and Grzegorz W. Basak |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1733641467 | ||
| 003 | DE-627 | ||
| 005 | 20241227002704.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200923s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3389/fimmu.2020.01537 |2 doi | |
| 035 | |a (DE-627)1733641467 | ||
| 035 | |a (DE-599)KXP1733641467 | ||
| 035 | |a (OCoLC)1341361148 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Frankiewicz, Andrzej |e VerfasserIn |0 (DE-588)121819622X |0 (DE-627)1733642064 |4 aut | |
| 245 | 1 | 0 | |a Association of country-specific socioeconomic factors with survival of patients who experience severe classic acute graft-vs.-host disease after allogeneic hematopoietic cell transplantation |b an analysis from the transplant complications working party of the EBMT |c Andrzej Frankiewicz, Christophe Peczynski, Sebastian Giebel, Alenca Harrington, Gerard Socié, Dietger Niederwieser, Christoph Scheid, Martin Bornhäuser, Nicolaus Kröger, Ahmet Elmaagacli, Boris Afanasyev, Peter Dreger, Claudia Rössig, Didier Blaise, Christian Kratz, Ibrahim Yakoub-Agha, Bernhard Kremens, Charlotte Marie Niemeyer, Gerald Wulf, Igor Blau, Olaf Penack, Hildegard Greinix and Grzegorz W. Basak |
| 264 | 1 | |c 23 July 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 23.09.2020 | ||
| 520 | |a Acute graft-versus-host disease (aGvHD) is one of the most frequent causes of transplant-related mortality (TRM) after allogeneic hematopoietic cell transplantation (alloHCT). Its treatment is complex and costly. The aim of this study was to retrospectively analyze the impact of country-specific socioeconomic factors on outcome of patients who experience severe aGvHD. Adults with hematological malignancies receiving alloHCT from either HLA-matched siblings (n=1328) or unrelated donors (n=2824) developing grade 3 or 4 aGvHD were included. In univariate analysis, the probability of TRM at 2 years was increased for countries with lower current Health Care Expenditure (HCE, p=0.04), lower HCE as % of Gross Domestic Product per capita (p=0.003) and lower values of the Human Development Index (p=0.02). In a multivariate model, the risk of TRM was most strongly predicted by current HCE (HR=0.76, p=0.006). HCE >median was also associated with reduced risk of the overall mortality (HR 0.73, p=0.0006) and reduced risk of treatment failure (either relapse or TRM; HR 0.77, p=0.004). We conclude that country-specific socioeconomic factors, in particular current HCE, are strongly associated with survival of patients who experience severe aGvHD. | ||
| 650 | 4 | |a Acute graft-versus-host disease | |
| 650 | 4 | |a Health care expenditure | |
| 650 | 4 | |a Hematopoietic Cell Transplantation | |
| 650 | 4 | |a Human Development Index | |
| 650 | 4 | |a Transplant-related mortality | |
| 700 | 1 | |a Peczynski, Christophe |e VerfasserIn |4 aut | |
| 700 | 1 | |a Giebel, Sebastian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Harrington, Alenca |e VerfasserIn |4 aut | |
| 700 | 1 | |a Socié, Gerard |e VerfasserIn |4 aut | |
| 700 | 1 | |8 1\p |a Niederwieser, Dietger |d 1952- |e VerfasserIn |0 (DE-588)1073549313 |0 (DE-627)829149120 |0 (DE-576)435151215 |4 aut | |
| 700 | 1 | |8 2\p |a Scheid, Christoph |e VerfasserIn |0 (DE-588)1075475244 |0 (DE-627)833299670 |0 (DE-576)443494495 |4 aut | |
| 700 | 1 | |8 3\p |a Bornhäuser, Martin |d 1966- |e VerfasserIn |0 (DE-588)1167559118 |0 (DE-627)1031176071 |0 (DE-576)511198817 |4 aut | |
| 700 | 1 | |8 4\p |a Kröger, Nicolaus |d 1959- |e VerfasserIn |0 (DE-588)112156533 |0 (DE-627)477107354 |0 (DE-576)167115103 |4 aut | |
| 700 | 1 | |a Elmaagacli, Ahmet |e VerfasserIn |4 aut | |
| 700 | 1 | |a Afanasyev, Boris |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dreger, Peter |e VerfasserIn |0 (DE-588)1028891881 |0 (DE-627)732699894 |0 (DE-576)376320966 |4 aut | |
| 700 | 1 | |8 5\p |a Rössig, Claudia |e VerfasserIn |0 (DE-588)1219583243 |0 (DE-627)1735501670 |4 aut | |
| 700 | 1 | |8 6\p |a Blaise, Didier |d 1955- |e VerfasserIn |0 (DE-588)1261106237 |0 (DE-627)1834173612 |4 aut | |
| 700 | 1 | |8 7\p |a Kratz, Christian Peter |d 1968- |e VerfasserIn |0 (DE-588)120208903 |0 (DE-627)080523536 |0 (DE-576)292097646 |4 aut | |
| 700 | 1 | |8 8\p |a Yakoub-Agha, Ibrahim |e VerfasserIn |0 (DE-588)1017074054 |0 (DE-627)690277938 |0 (DE-576)353090204 |4 aut | |
| 700 | 1 | |a Kremens, Bernhard |e VerfasserIn |4 aut | |
| 700 | 1 | |a Niemeyer, Charlotte Marie |e VerfasserIn |4 aut | |
| 700 | 1 | |8 9\p |a Wulf, Gerald |d 1966- |e VerfasserIn |0 (DE-588)172647010 |0 (DE-627)697580830 |0 (DE-576)133505766 |4 aut | |
| 700 | 1 | |a Blau, Igor |e VerfasserIn |4 aut | |
| 700 | 1 | |8 10\p |a Penack, Olaf |d 1971- |e VerfasserIn |0 (DE-588)123860938 |0 (DE-627)706454561 |0 (DE-576)293914265 |4 aut | |
| 700 | 1 | |8 11\p |a Greinix, Hildegard |e VerfasserIn |0 (DE-588)1195457626 |0 (DE-627)1677496614 |4 aut | |
| 700 | 1 | |8 12\p |a Basak, Grzegorz W. |e VerfasserIn |0 (DE-588)1115680587 |0 (DE-627)869893165 |0 (DE-576)477879888 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Frontiers in immunology |d Lausanne : Frontiers Media, 2010 |g 11(2020) Artikel-Nummer 1537, 10 Seiten |h Online-Ressource |w (DE-627)657998354 |w (DE-600)2606827-8 |w (DE-576)343624834 |x 1664-3224 |7 nnas |a Association of country-specific socioeconomic factors with survival of patients who experience severe classic acute graft-vs.-host disease after allogeneic hematopoietic cell transplantation an analysis from the transplant complications working party of the EBMT |
| 773 | 1 | 8 | |g volume:11 |g year:2020 |a Association of country-specific socioeconomic factors with survival of patients who experience severe classic acute graft-vs.-host disease after allogeneic hematopoietic cell transplantation an analysis from the transplant complications working party of the EBMT |
| 856 | 4 | 0 | |u https://doi.org/10.3389/fimmu.2020.01537 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.frontiersin.org/articles/10.3389/fimmu.2020.01537/full |x Verlag |z lizenzpflichtig |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 2\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 3\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 4\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 5\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 6\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 7\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 8\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 9\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 10\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 11\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 12\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20200923 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 1028891881 |a Dreger, Peter |m 1028891881:Dreger, Peter |d 910000 |d 910100 |e 910000PD1028891881 |e 910100PD1028891881 |k 0/910000/ |k 1/910000/910100/ |p 12 | ||
| 999 | |a KXP-PPN1733641467 |e 3760623018 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Andrzej Frankiewicz, Christophe Peczynski, Sebastian Giebel, Alenca Harrington, Gerard Socié, Dietger Niederwieser, Christoph Scheid, Martin Bornhäuser, Nicolaus Kröger, Ahmet Elmaagacli, Boris Afanasyev, Peter Dreger, Claudia Rössig, Didier Blaise, Christian Kratz, Ibrahim Yakoub-Agha, Bernhard Kremens, Charlotte Marie Niemeyer, Gerald Wulf, Igor Blau, Olaf Penack, Hildegard Greinix and Grzegorz W. Basak"]},"recId":"1733641467","note":["Gesehen am 23.09.2020"],"origin":[{"dateIssuedKey":"2020","dateIssuedDisp":"23 July 2020"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"eki":["1733641467"],"doi":["10.3389/fimmu.2020.01537"]},"language":["eng"],"title":[{"title_sort":"Association of country-specific socioeconomic factors with survival of patients who experience severe classic acute graft-vs.-host disease after allogeneic hematopoietic cell transplantation","title":"Association of country-specific socioeconomic factors with survival of patients who experience severe classic acute graft-vs.-host disease after allogeneic hematopoietic cell transplantation","subtitle":"an analysis from the transplant complications working party of the EBMT"}],"person":[{"role":"aut","display":"Frankiewicz, Andrzej","family":"Frankiewicz","given":"Andrzej"},{"family":"Peczynski","display":"Peczynski, Christophe","given":"Christophe","role":"aut"},{"display":"Giebel, Sebastian","family":"Giebel","given":"Sebastian","role":"aut"},{"role":"aut","family":"Harrington","display":"Harrington, Alenca","given":"Alenca"},{"family":"Socié","display":"Socié, Gerard","given":"Gerard","role":"aut"},{"role":"aut","given":"Dietger","display":"Niederwieser, Dietger","family":"Niederwieser"},{"display":"Scheid, Christoph","family":"Scheid","given":"Christoph","role":"aut"},{"role":"aut","display":"Bornhäuser, Martin","family":"Bornhäuser","given":"Martin"},{"family":"Kröger","display":"Kröger, Nicolaus","given":"Nicolaus","role":"aut"},{"role":"aut","given":"Ahmet","family":"Elmaagacli","display":"Elmaagacli, Ahmet"},{"role":"aut","given":"Boris","family":"Afanasyev","display":"Afanasyev, Boris"},{"family":"Dreger","display":"Dreger, Peter","given":"Peter","role":"aut"},{"display":"Rössig, Claudia","family":"Rössig","given":"Claudia","role":"aut"},{"display":"Blaise, Didier","family":"Blaise","given":"Didier","role":"aut"},{"role":"aut","given":"Christian Peter","family":"Kratz","display":"Kratz, Christian Peter"},{"role":"aut","family":"Yakoub-Agha","display":"Yakoub-Agha, Ibrahim","given":"Ibrahim"},{"display":"Kremens, Bernhard","family":"Kremens","given":"Bernhard","role":"aut"},{"given":"Charlotte Marie","family":"Niemeyer","display":"Niemeyer, Charlotte Marie","role":"aut"},{"role":"aut","given":"Gerald","family":"Wulf","display":"Wulf, Gerald"},{"role":"aut","family":"Blau","display":"Blau, Igor","given":"Igor"},{"role":"aut","given":"Olaf","family":"Penack","display":"Penack, Olaf"},{"display":"Greinix, Hildegard","family":"Greinix","given":"Hildegard","role":"aut"},{"role":"aut","given":"Grzegorz W.","display":"Basak, Grzegorz W.","family":"Basak"}],"relHost":[{"disp":"Association of country-specific socioeconomic factors with survival of patients who experience severe classic acute graft-vs.-host disease after allogeneic hematopoietic cell transplantation an analysis from the transplant complications working party of the EBMTFrontiers in immunology","note":["Gesehen am 07.11.13"],"pubHistory":["1.2010 -"],"recId":"657998354","origin":[{"publisher":"Frontiers Media","dateIssuedKey":"2010","publisherPlace":"Lausanne","dateIssuedDisp":"2010-"}],"language":["eng"],"id":{"zdb":["2606827-8"],"issn":["1664-3224"],"eki":["657998354"]},"type":{"bibl":"periodical","media":"Online-Ressource"},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Frontiers in immunology","title":"Frontiers in immunology"}],"part":{"text":"11(2020) Artikel-Nummer 1537, 10 Seiten","year":"2020","volume":"11"}}]} | ||
| SRT | |a FRANKIEWICASSOCIATIO2320 | ||