Biomarkers of periodontitis and inflammation in ischemic stroke: A case-control study
Periodontitis is a common infectious disease associated with increased risk for ischemic stroke though presently unclear mechanisms. In a case-control study, we investigated salivary levels of four periodontal pathogens, as well as systemic and local inflammatory markers. The population comprised 98...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2014
|
| In: |
Innate immunity
Year: 2014, Jahrgang: 20, Heft: 5, Pages: 511-518 |
| ISSN: | 1753-4267 |
| DOI: | 10.1177/1753425913501214 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1177/1753425913501214 Verlag, lizenzpflichtig, Volltext: https://journals.sagepub.com/doi/10.1177/1753425913501214 
|
| Verfasserangaben: | Frederick Palm, Laura Lahdentausta, Timo Sorsa, Taina Tervahartiala, Pia Gokel, Florian Buggle, Anton Safer, Heiko Becher, Armin J. Grau and Pirkko Pussinen |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1733692177 | ||
| 003 | DE-627 | ||
| 005 | 20230426163445.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200924s2014 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1177/1753425913501214 |2 doi | |
| 035 | |a (DE-627)1733692177 | ||
| 035 | |a (DE-599)KXP1733692177 | ||
| 035 | |a (OCoLC)1341361689 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Palm, Frederick |d 1977- |e VerfasserIn |0 (DE-588)124976026 |0 (DE-627)706750896 |0 (DE-576)294598022 |4 aut | |
| 245 | 1 | 0 | |a Biomarkers of periodontitis and inflammation in ischemic stroke |b A case-control study |c Frederick Palm, Laura Lahdentausta, Timo Sorsa, Taina Tervahartiala, Pia Gokel, Florian Buggle, Anton Safer, Heiko Becher, Armin J. Grau and Pirkko Pussinen |
| 264 | 1 | |c 2014 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Article first published online: September 17, 2013 | ||
| 500 | |a Gesehen am 24.09.2020 | ||
| 520 | |a Periodontitis is a common infectious disease associated with increased risk for ischemic stroke though presently unclear mechanisms. In a case-control study, we investigated salivary levels of four periodontal pathogens, as well as systemic and local inflammatory markers. The population comprised 98 patients with acute ischemic stroke (mean ± SD, 68.2 ± 9.7 yrs; 45.9% women) and 100 healthy controls (69.1 ± 5.2 yrs; 47.0% women). Patients were more often edentulous and had fewer teeth than controls (13.8 ± 10.8 versus 16.6 ± 10.1). After adjusting for stroke risk factors and number of teeth, controls had higher saliva matrix metalloproteinase-8 (MMP-8), myeloperoxidase (MPO), IL-1β, Aggregatibacter actinomycetemcomitans, and serum LPS activity levels. Patients had higher serum MMP-8 and MPO, and they were more often qPCR-positive for A. actinomycetemcomitans (37.9% versus 19.0%) and for ≥3 periodontopathic species combined (50.0% versus 33.0%). We conclude that controls more often had evidence of current periodontal infection with higher periodontal pathogen amount, endotoxemia, local inflammation and tissue destruction. Stroke patients more often had evidence of end-stage periodontitis with edentulism and missing teeth. They were more often carriers of several periodontopathic pathogens in saliva, especially A. actinomycetemcomitans. Additionally, inflammatory burden may contribute to high systemic inflammation associated with elevated stroke susceptibility. | ||
| 700 | 1 | |a Becher, Heiko |e VerfasserIn |0 (DE-588)1027740677 |0 (DE-627)729629260 |0 (DE-576)375063439 |4 aut | |
| 700 | 1 | |a Grau, Armin J. |d 1959- |e VerfasserIn |0 (DE-588)1064028012 |0 (DE-627)812878906 |0 (DE-576)423571184 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Innate immunity |d Thousand Oaks, Calif. : Sage, 2008 |g 20(2014), 5, Seite 511-518 |h Online-Ressource |w (DE-627)539000159 |w (DE-600)2381250-3 |w (DE-576)278428231 |x 1753-4267 |7 nnas |a Biomarkers of periodontitis and inflammation in ischemic stroke A case-control study |
| 773 | 1 | 8 | |g volume:20 |g year:2014 |g number:5 |g pages:511-518 |g extent:8 |a Biomarkers of periodontitis and inflammation in ischemic stroke A case-control study |
| 856 | 4 | 0 | |u https://doi.org/10.1177/1753425913501214 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://journals.sagepub.com/doi/10.1177/1753425913501214 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200924 | ||
| 993 | |a Article | ||
| 994 | |a 2014 | ||
| 998 | |g 1064028012 |a Grau, Armin J. |m 1064028012:Grau, Armin J. |d 50000 |e 50000PG1064028012 |k 0/50000/ |p 9 | ||
| 998 | |g 1027740677 |a Becher, Heiko |m 1027740677:Becher, Heiko |d 910000 |d 911700 |e 910000PB1027740677 |e 911700PB1027740677 |k 0/910000/ |k 1/910000/911700/ |p 8 | ||
| 999 | |a KXP-PPN1733692177 |e 3760977707 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1733692177","language":["eng"],"name":{"displayForm":["Frederick Palm, Laura Lahdentausta, Timo Sorsa, Taina Tervahartiala, Pia Gokel, Florian Buggle, Anton Safer, Heiko Becher, Armin J. Grau and Pirkko Pussinen"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.1177/1753425913501214"],"eki":["1733692177"]},"origin":[{"dateIssuedDisp":"2014","dateIssuedKey":"2014"}],"note":["Article first published online: September 17, 2013","Gesehen am 24.09.2020"],"physDesc":[{"extent":"8 S."}],"relHost":[{"pubHistory":["14.2008 -"],"id":{"eki":["539000159"],"issn":["1753-4267"],"zdb":["2381250-3"]},"recId":"539000159","physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"Thousand Oaks, Calif.","dateIssuedKey":"2008","dateIssuedDisp":"2008-","publisher":"Sage"}],"note":["Gesehen am 10.02.2021","Fortsetzung der Druck-Ausgabe"],"disp":"Biomarkers of periodontitis and inflammation in ischemic stroke A case-control studyInnate immunity","type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"part":{"issue":"5","text":"20(2014), 5, Seite 511-518","pages":"511-518","extent":"8","year":"2014","volume":"20"},"title":[{"title":"Innate immunity","title_sort":"Innate immunity"}]}],"person":[{"given":"Frederick","family":"Palm","display":"Palm, Frederick","role":"aut"},{"family":"Becher","given":"Heiko","display":"Becher, Heiko","role":"aut"},{"family":"Grau","given":"Armin J.","role":"aut","display":"Grau, Armin J."}],"title":[{"subtitle":"A case-control study","title_sort":"Biomarkers of periodontitis and inflammation in ischemic stroke","title":"Biomarkers of periodontitis and inflammation in ischemic stroke"}]} | ||
| SRT | |a PALMFREDERBIOMARKERS2014 | ||