A scintillator-based range telescope for particle therapy

The commissioning and operation of a particle therapy centre requires an extensive set of detectors for measuring various parameters of the treatment beam. Among the key devices are detectors for beam range quality assurance. In this work, a novel range telescope based on a plastic scintillator and...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Kelleter, Laurent (VerfasserIn) , Radogna, Raffaella (VerfasserIn) , Volz, Lennart (VerfasserIn) , Attree, Derek (VerfasserIn) , Basharina-Freshville, Anastasia (VerfasserIn) , Seco, Joao (VerfasserIn) , Saakyan, Ruben (VerfasserIn) , Jolly, Simon (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 10 August 2020
In: Physics in medicine and biology
Year: 2020, Jahrgang: 65, Heft: 16
ISSN:1361-6560
DOI:10.1088/1361-6560/ab9415
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1088/1361-6560/ab9415
Volltext
Verfasserangaben:Laurent Kelleter, Raffaella Radogna, Lennart Volz, Derek Attree, Anastasia Basharina-Freshville, Joao Seco, Ruben Saakyan and Simon Jolly

MARC

LEADER 00000caa a2200000 c 4500
001 1733719008
003 DE-627
005 20230426163446.0
007 cr uuu---uuuuu
008 200925s2020 xx |||||o 00| ||eng c
024 7 |a 10.1088/1361-6560/ab9415  |2 doi 
035 |a (DE-627)1733719008 
035 |a (DE-599)KXP1733719008 
035 |a (OCoLC)1341361638 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 29  |2 sdnb 
100 1 |a Kelleter, Laurent  |e VerfasserIn  |0 (DE-588)1163751529  |0 (DE-627)1028110375  |0 (DE-576)508192129  |4 aut 
245 1 2 |a A scintillator-based range telescope for particle therapy  |c Laurent Kelleter, Raffaella Radogna, Lennart Volz, Derek Attree, Anastasia Basharina-Freshville, Joao Seco, Ruben Saakyan and Simon Jolly 
264 1 |c 10 August 2020 
300 |a 14 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 25.09.2020 
520 |a The commissioning and operation of a particle therapy centre requires an extensive set of detectors for measuring various parameters of the treatment beam. Among the key devices are detectors for beam range quality assurance. In this work, a novel range telescope based on a plastic scintillator and read out by a large-scale CMOS sensor is presented. The detector is made of a stack of 49 plastic scintillator sheets with a thickness of 2-3 mm and an active area of 100 × 100 mm2, resulting in a total physical stack thickness of 124.2 mm. This compact design avoids optical artefacts that are common in other scintillation detectors. The range of a proton beam is reconstructed using a novel Bragg curve model that incorporates scintillator quenching effects. Measurements to characterise the performance of the detector were carried out at the Heidelberger Ionenstrahl-Therapiezentrum (HIT, Heidelberg, GER) and the Clatterbridge Cancer Centre (CCC, Bebington, UK). The maximum difference between the measured range and the reference range was found to be 0.41 mm at a proton beam range of 310 mm and was dominated by detector alignment uncertainties. With the new detector prototype, the water-equivalent thickness of PMMA degrader blocks has been reconstructed within ± 0.1 mm. An evaluation of the radiation hardness proves that the range reconstruction algorithm is robust following the deposition of 6,300 Gy peak dose into the detector. Furthermore, small variations in the beam spot size and transverse beam position are shown to have a negligible effect on the range reconstruction accuracy. The potential for range measurements of ion beams is also investigated. 
700 1 |a Radogna, Raffaella  |e VerfasserIn  |4 aut 
700 1 |a Volz, Lennart  |d 1992-  |e VerfasserIn  |0 (DE-588)1164508121  |0 (DE-627)1028942141  |0 (DE-576)510057004  |4 aut 
700 1 |a Attree, Derek  |e VerfasserIn  |4 aut 
700 1 |a Basharina-Freshville, Anastasia  |e VerfasserIn  |4 aut 
700 1 |a Seco, Joao  |e VerfasserIn  |0 (DE-588)1120955866  |0 (DE-627)874146615  |0 (DE-576)480627010  |4 aut 
700 1 |a Saakyan, Ruben  |e VerfasserIn  |4 aut 
700 1 |a Jolly, Simon  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Physics in medicine and biology  |d Bristol : IOP Publ., 1956  |g 65(2020,16) Artikel-Nummer 165001, 14 Seiten  |h Online-Ressource  |w (DE-627)269016163  |w (DE-600)1473501-5  |w (DE-576)088704130  |x 1361-6560  |7 nnas  |a A scintillator-based range telescope for particle therapy 
773 1 8 |g volume:65  |g year:2020  |g number:16  |g extent:14  |a A scintillator-based range telescope for particle therapy 
856 4 0 |u https://doi.org/10.1088/1361-6560/ab9415  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20200925 
993 |a Article 
994 |a 2020 
998 |g 1120955866  |a Seco, Joao  |m 1120955866:Seco, Joao  |d 130000  |e 130000PS1120955866  |k 0/130000/  |p 6 
998 |g 1164508121  |a Volz, Lennart  |m 1164508121:Volz, Lennart  |d 130000  |e 130000PV1164508121  |k 0/130000/  |p 3 
999 |a KXP-PPN1733719008  |e 3761056788 
BIB |a Y 
SER |a journal 
JSO |a {"id":{"eki":["1733719008"],"doi":["10.1088/1361-6560/ab9415"]},"name":{"displayForm":["Laurent Kelleter, Raffaella Radogna, Lennart Volz, Derek Attree, Anastasia Basharina-Freshville, Joao Seco, Ruben Saakyan and Simon Jolly"]},"recId":"1733719008","physDesc":[{"extent":"14 S."}],"title":[{"title":"A scintillator-based range telescope for particle therapy","title_sort":"scintillator-based range telescope for particle therapy"}],"note":["Gesehen am 25.09.2020"],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"relHost":[{"part":{"extent":"14","text":"65(2020,16) Artikel-Nummer 165001, 14 Seiten","volume":"65","issue":"16","year":"2020"},"title":[{"title":"Physics in medicine and biology","title_sort":"Physics in medicine and biology","subtitle":"an official journal of the Institute of Physics and Engineering in Medicine"}],"id":{"zdb":["1473501-5"],"issn":["1361-6560"],"eki":["269016163"]},"note":["Gesehen am 28.01.2019","Fortsetzung der Druck-Ausgabe"],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"pubHistory":["1.1956 -"],"origin":[{"publisher":"IOP Publ.","dateIssuedKey":"1956","dateIssuedDisp":"1956-","publisherPlace":"Bristol"}],"disp":"A scintillator-based range telescope for particle therapyPhysics in medicine and biology","recId":"269016163","physDesc":[{"extent":"Online-Ressource"}]}],"person":[{"display":"Kelleter, Laurent","given":"Laurent","role":"aut","family":"Kelleter"},{"display":"Radogna, Raffaella","family":"Radogna","role":"aut","given":"Raffaella"},{"family":"Volz","role":"aut","given":"Lennart","display":"Volz, Lennart"},{"given":"Derek","role":"aut","family":"Attree","display":"Attree, Derek"},{"family":"Basharina-Freshville","given":"Anastasia","role":"aut","display":"Basharina-Freshville, Anastasia"},{"display":"Seco, Joao","given":"Joao","role":"aut","family":"Seco"},{"display":"Saakyan, Ruben","family":"Saakyan","given":"Ruben","role":"aut"},{"display":"Jolly, Simon","family":"Jolly","given":"Simon","role":"aut"}],"origin":[{"dateIssuedDisp":"10 August 2020","dateIssuedKey":"2020"}]} 
SRT |a KELLETERLASCINTILLAT1020