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Evaluation of ultrafast wave-CAIPI MPRAGE for visual grading and automated measurement of brain tissue volume

BACKGROUND AND PURPOSE: Volumetric brain MR imaging typically has long acquisition times. We sought to evaluate an ultrafast MPRAGE sequence based on Wave-CAIPI (Wave-MPRAGE) compared with standard MPRAGE for evaluation of regional brain tissue volumes. MATERIALS AND METHODS: We performed scan-resca...

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Hauptverfasser: Longo, Maria Gabriela (VerfasserIn) , Conklin, J. (VerfasserIn) , Cauley, S. F. (VerfasserIn) , Setsompop, K. (VerfasserIn) , Tian, Q. (VerfasserIn) , Polak, Daniel (VerfasserIn) , Polackal, M. (VerfasserIn) , Splitthoff, D. (VerfasserIn) , Liu, W. (VerfasserIn) , Gonzalez, R. G. (VerfasserIn) , Schaefer, P. W. (VerfasserIn) , Kirsch, J. E. (VerfasserIn) , Rapalino, O. (VerfasserIn) , Huang, S. Y. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: Aug 2020
In: American journal of neuroradiology
Year: 2020, Jahrgang: 41, Heft: 8, Pages: 1388-1396
ISSN:1936-959X
DOI:10.3174/ajnr.A6703
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3174/ajnr.A6703
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Verfasserangaben:M.G.F. Longo, J. Conklin, S.F. Cauley, K. Setsompop, Q. Tian, D. Polak, M. Polackal, D. Splitthoff, W. Liu, R. G. Gonzalez, P.W. Schaefer, J.E. Kirsch, O. Rapalino, S.Y. Huang
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Zusammenfassung:BACKGROUND AND PURPOSE: Volumetric brain MR imaging typically has long acquisition times. We sought to evaluate an ultrafast MPRAGE sequence based on Wave-CAIPI (Wave-MPRAGE) compared with standard MPRAGE for evaluation of regional brain tissue volumes. MATERIALS AND METHODS: We performed scan-rescan experiments in 10 healthy volunteers to evaluate the intraindividual variability of the brain volumes measured using the standard and Wave-MPRAGE sequences. We then evaluated 43 consecutive patients undergoing brain MR imaging. Patients underwent 3T brain MR imaging, including a standard MPRAGE sequence (acceleration factor [R] = 2, acquisition time [TA] = 5.2 minutes) and an ultrafast Wave-MPRAGE sequence (R= 9, TA = 1.15 minutes for the 32-channel coil;R= 6, TA = 1.75 minutes for the 20-channel coil). Automated segmentation of regional brain volume was performed. Two radiologists evaluated regional brain atrophy using semiquantitative visual rating scales. RESULTS: The mean absolute symmetrized percent change in the healthy volunteers participating in the scan-rescan experiments was not statistically different in any brain region for both the standard and Wave-MPRAGE sequences. In the patients undergoing evaluation for neurodegenerative disease, the Dice coefficient of similarity between volumetric measurements obtained from standard and Wave-MPRAGE ranged from 0.86 to 0.95. Similarly, for all regions, the absolute symmetrized percent change for brain volume and cortical thickness showed <6% difference between the 2 sequences. In the semiquantitative visual comparison, the differences between the 2 radiologists' scores were not clinically or statistically significant. CONCLUSIONS: Brain volumes estimated using ultrafast Wave-MPRAGE show low intraindividual variability and are comparable with those estimated using standard MPRAGE in patients undergoing clinical evaluation for suspected neurodegenerative disease.
Beschreibung:Gesehen am 25.09.2020
Beschreibung:Online Resource
ISSN:1936-959X
DOI:10.3174/ajnr.A6703

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