Cytosolic peroxidases protect the lysosome of bloodstream African trypanosomes from iron-mediated membrane damage
African trypanosomes express three virtually identical non-selenium glutathione peroxidase (Px)-type enzymes which preferably detoxify lipid-derived hydroperoxides. As shown previously, bloodstream Trypanosoma brucei lacking the mitochondrial Px III display only a weak and transient proliferation de...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
April 10, 2014
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| In: |
PLoS pathogens
Year: 2014, Jahrgang: 10, Heft: 4 |
| ISSN: | 1553-7374 |
| DOI: | 10.1371/journal.ppat.1004075 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.ppat.1004075 Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1004075 
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| Verfasserangaben: | Corinna Hiller, Amrei Nissen, Diego Benítez, Marcelo A. Comini, R. Luise Krauth-Siegel |
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| 520 | |a African trypanosomes express three virtually identical non-selenium glutathione peroxidase (Px)-type enzymes which preferably detoxify lipid-derived hydroperoxides. As shown previously, bloodstream Trypanosoma brucei lacking the mitochondrial Px III display only a weak and transient proliferation defect whereas parasites that lack the cytosolic Px I and Px II undergo extremely fast lipid peroxidation and cell lysis. The phenotype can completely be rescued by supplementing the medium with the α-tocopherol derivative Trolox. | ||
| 650 | 4 | |a Cell staining | |
| 650 | 4 | |a Cellular structures and organelles | |
| 650 | 4 | |a Lysosomes | |
| 650 | 4 | |a Mitochondria | |
| 650 | 4 | |a Parasitic diseases | |
| 650 | 4 | |a Peroxidases | |
| 650 | 4 | |a Trypanosoma | |
| 650 | 4 | |a Trypanosoma brucei gambiense | |
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