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Structural differences explain diverse functions of Plasmodium actins

Actins are highly conserved proteins and key players in central processes in all eukaryotic cells. The two actins of the malaria parasite are among the most divergent eukaryotic actins and also differ from each other more than isoforms in any other species. Microfilaments have not been directly obse...

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Hauptverfasser: Vahokoski, Juha (VerfasserIn) , Bhargav, Saligram Prabhakar (VerfasserIn) , Desfosses, Ambroise (VerfasserIn) , Andreadaki, Maria (VerfasserIn) , Kumpula, Esa-Pekka (VerfasserIn) , Martinez, Silvia Muñico (VerfasserIn) , Ignatev, Alexander (VerfasserIn) , Lepper, Simone (VerfasserIn) , Frischknecht, Friedrich (VerfasserIn) , Sidén-Kiamos, Inga (VerfasserIn) , Sachse, Carsten (VerfasserIn) , Kursula, Inari (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: April 17, 2014
In: PLoS pathogens
Year: 2014, Jahrgang: 10, Heft: 4
ISSN:1553-7374
DOI:10.1371/journal.ppat.1004091
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.ppat.1004091
Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1004091
Volltext
Verfasserangaben:Juha Vahokoski, Saligram Prabhakar Bhargav, Ambroise Desfosses, Maria Andreadaki, Esa-Pekka Kumpula, Silvia Muñico Martinez, Alexander Ignatev, Simone Lepper, Friedrich Frischknecht, Inga Sidén-Kiamos, Carsten Sachse, Inari Kursula
Beschreibung
Zusammenfassung:Actins are highly conserved proteins and key players in central processes in all eukaryotic cells. The two actins of the malaria parasite are among the most divergent eukaryotic actins and also differ from each other more than isoforms in any other species. Microfilaments have not been directly observed in Plasmodium and are presumed to be short and highly dynamic. We show that actin I cannot complement actin II in male gametogenesis, suggesting critical structural differences.
Beschreibung:Gesehen am 25.09.2020
Beschreibung:Online Resource
ISSN:1553-7374
DOI:10.1371/journal.ppat.1004091

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