Mouse models of nonalcoholic steatohepatitis: head-to-head comparison of dietary models and impact on inflammation and animal welfare
A variety of dietary nonalcoholic steatohepatitis (NASH) mouse models are available, and choosing the appropriate mouse model is one of the most important steps in the design of NASH studies. In addition to the histopathological and metabolic findings of NASH, a sufficient mouse model should guarant...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
13 July 2020
|
| In: |
Gastroenterology research and practice
|
| ISSN: | 1687-630X |
| DOI: | 10.1155/2020/7347068 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1155/2020/7347068 Verlag, Volltext: https://www.hindawi.com/journals/grp/2020/7347068/ 
|
| Author Notes: | Andreas Kroh, Vanina Ivanova, Hannah Drescher, Julia Andruszkow, Thomas Longerich, Jochen Nolting, Roman Eickhoff, D. Heise, Karl P. Rheinwalt, Ulf P. Neumann, and Florian T. Ulmer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1733863168 | ||
| 003 | DE-627 | ||
| 005 | 20230426163456.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 200928s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1155/2020/7347068 |2 doi | |
| 035 | |a (DE-627)1733863168 | ||
| 035 | |a (DE-599)KXP1733863168 | ||
| 035 | |a (OCoLC)1341367788 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kroh, Andreas |d 1984- |e VerfasserIn |0 (DE-588)1047316439 |0 (DE-627)778099830 |0 (DE-576)400890542 |4 aut | |
| 245 | 1 | 0 | |a Mouse models of nonalcoholic steatohepatitis |b head-to-head comparison of dietary models and impact on inflammation and animal welfare |c Andreas Kroh, Vanina Ivanova, Hannah Drescher, Julia Andruszkow, Thomas Longerich, Jochen Nolting, Roman Eickhoff, D. Heise, Karl P. Rheinwalt, Ulf P. Neumann, and Florian T. Ulmer |
| 264 | 1 | |c 13 July 2020 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 28.09.2020 | ||
| 520 | |a A variety of dietary nonalcoholic steatohepatitis (NASH) mouse models are available, and choosing the appropriate mouse model is one of the most important steps in the design of NASH studies. In addition to the histopathological and metabolic findings of NASH, a sufficient mouse model should guarantee a robust clinical status and good animal welfare. Three different NASH diets, a high-fat diet (HFD60), a western diet (WD), and a cafeteria diet (CAFD), were fed for 12 or 16 weeks. Metabolic assessment was conducted at baseline and before scheduled sacrifice, and liver inflammation was analyzed via fluorescence-associated cell sorting and histopathological examination. Clinical health conditions were scored weekly to assess the impact on animal welfare. The HFD60 and WD were identified as suitable NASH mouse models without a significant strain on animal welfare. Furthermore, the progression of inflammation and liver fibrosis was associated with a decreased proportion of CD3+ NK1.1+ cells. The WD represents a model of advanced-stage NASH, and the HFD60 is a strong model of nonalcoholic fatty liver disease (NAFLD) and metabolic syndrome. However, the CAFD should not be considered a NASH model. | ||
| 700 | 1 | |a Longerich, Thomas |d 1974- |e VerfasserIn |0 (DE-588)128494514 |0 (DE-627)373916124 |0 (DE-576)297178059 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Gastroenterology research and practice |d [Hoboken, NJ : Wiley], 2008 |g (2020) Artikel-Nummer 7347068, 12 Seiten |h Online-Ressource |w (DE-627)571608647 |w (DE-600)2435460-0 |w (DE-576)283869534 |x 1687-630X |7 nnas |a Mouse models of nonalcoholic steatohepatitis head-to-head comparison of dietary models and impact on inflammation and animal welfare |
| 773 | 1 | 8 | |g year:2020 |g extent:12 |a Mouse models of nonalcoholic steatohepatitis head-to-head comparison of dietary models and impact on inflammation and animal welfare |
| 856 | 4 | 0 | |u https://doi.org/10.1155/2020/7347068 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.hindawi.com/journals/grp/2020/7347068/ |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20200928 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 128494514 |a Longerich, Thomas |m 128494514:Longerich, Thomas |d 910000 |d 912000 |e 910000PL128494514 |e 912000PL128494514 |k 0/910000/ |k 1/910000/912000/ |p 5 | ||
| 999 | |a KXP-PPN1733863168 |e 3763701605 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 28.09.2020"],"recId":"1733863168","name":{"displayForm":["Andreas Kroh, Vanina Ivanova, Hannah Drescher, Julia Andruszkow, Thomas Longerich, Jochen Nolting, Roman Eickhoff, D. Heise, Karl P. Rheinwalt, Ulf P. Neumann, and Florian T. Ulmer"]},"physDesc":[{"extent":"12 S."}],"id":{"doi":["10.1155/2020/7347068"],"eki":["1733863168"]},"origin":[{"dateIssuedDisp":"13 July 2020","dateIssuedKey":"2020"}],"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"pubHistory":["1.2008 -"],"part":{"text":"(2020) Artikel-Nummer 7347068, 12 Seiten","extent":"12","year":"2020"},"recId":"571608647","note":["Gesehen am 27.07.2021"],"id":{"doi":["10.1155/GRP"],"issn":["1687-630X"],"eki":["571608647"],"zdb":["2435460-0"]},"language":["eng"],"disp":"Mouse models of nonalcoholic steatohepatitis head-to-head comparison of dietary models and impact on inflammation and animal welfareGastroenterology research and practice","origin":[{"dateIssuedDisp":"2024-","publisher":"Wiley] ; Hindawi","publisherPlace":"[Hoboken, NJ ; New York, NY","dateIssuedKey":"2024"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Gastroenterology research and practice","title":"Gastroenterology research and practice"}]}],"person":[{"family":"Kroh","given":"Andreas","roleDisplay":"VerfasserIn","role":"aut","display":"Kroh, Andreas"},{"given":"Thomas","roleDisplay":"VerfasserIn","role":"aut","display":"Longerich, Thomas","family":"Longerich"}],"language":["eng"],"title":[{"subtitle":"head-to-head comparison of dietary models and impact on inflammation and animal welfare","title_sort":"Mouse models of nonalcoholic steatohepatitis","title":"Mouse models of nonalcoholic steatohepatitis"}]} | ||
| SRT | |a KROHANDREAMOUSEMODEL1320 | ||