FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium

Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped sing...

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Main Authors: Agarwal, Deepak K. (Author) , Brauch, Hiltrud (Author) , Brüning, Thomas (Author) , Hamann, Ute (Author) , Marmé, Frederik (Author) , Burwinkel, Barbara (Author) , Brenner, Hermann (Author) , Dieffenbach, Aida Karina (Author) , Arndt, Volker (Author) , Chang-Claude, Jenny (Author) , Rudolph, Anja (Author) , Seibold, Petra Beate (Author)
Format: Article (Journal)
Language:English
Published: 18 February 2014
In: British journal of cancer
Year: 2014, Volume: 110, Issue: 4, Pages: 1088-1100
ISSN:1532-1827
DOI:10.1038/bjc.2013.769
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/bjc.2013.769
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/bjc2013769
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Author Notes:D. Agarwal, S. Pineda, K. Michailidou, J. Herranz, G. Pita, L.T. Moreno, M.R. Alonso, J. Dennis, Q. Wang, M.K. Bolla, K.B. Meyer, P. Menéndez-Rodríguez, D. Hardisson, M. Mendiola, A. González-Neira, A. Lindblom, S. Margolin, A. Swerdlow, A. Ashworth, N. Orr, M. Jones, K. Matsuo, H. Ito, H. Iwata, N. Kondo, M. Hartman, M. Hui, W.Y. Lim, P.T.-C. Iau, E. Sawyer, I. Tomlinson, M. Kerin, N. Miller, D. Kang, J.-Y. Choi, S.K. Park, D.-Y. Noh, J.L. Hopper, D.F. Schmidt, E. Makalic, M.C. Southey, S.H. Teo, C.H. Yip, K. Sivanandan, W.-T. Tay, H. Brauch, T. Brüning, U. Hamann, A.M. Dunning, M. Shah, I.L. Andrulis, J.A. Knight, G. Glendon, S. Tchatchou, M.K. Schmidt, A. Broeks, E.H. Rosenberg, L. J. van't Veer, P.A. Fasching, S.P. Renner, A.B. Ekici, M.W. Beckmann, C.-Y. Shen, C.-N. Hsiung, J.-C. Yu, M.-F. Hou, W. Blot, Q. Cai, A.H. Wu, C.-C. Tseng, D. Van Den Berg, D.O. Stram, A. Cox, I.W. Brock, M.W.R. Reed, K. Muir, A. Lophatananon, S. Stewart-Brown, P. Siriwanarangsan, W. Zheng, S. Deming-Halverson, M.J. Shrubsole, J. Long, X.-O. Shu, W. Lu, Y.-T. Gao, B. Zhang, P. Radice, P. Peterlongo, S. Manoukian, F. Mariette, S. Sangrajrang, J. McKay, F.J. Couch, A.E. Toland, D. Yannoukakos, O. Fletcher, N. Johnson, I. dos Santos Silva, J. Peto, F. Marme, B. Burwinkel, P. Guénel, T. Truong, M. Sanchez, C. Mulot, S.E. Bojesen, B.G. Nordestgaard, H. Flyer, H. Brenner, A.K. Dieffenbach, V. Arndt, C. Stegmaier, A. Mannermaa, V. Kataja, V.-M. Kosma, J.M. Hartikainen, D. Lambrechts, B.T. Yesilyurt, G. Floris, K. Leunen, J. Chang-Claude, A. Rudolph, P. Seibold, D. Flesch-Janys, X. Wang, J.E. Olson, C. Vachon, K. Purrington, G.G. Giles, G. Severi, L. Baglietto, C.A. Haiman, B.E. Henderson, F. Schumacher, L. Le Marchand, J. Simard, M. Dumont, M. S. Goldberg, F. Labrèche, R. Winqvist, K. Pylkäs, A. Jukkola-Vuorinen, M. Grip, P. Devilee, R.a.E.M. Tollenaar, C. Seynaeve, M. García-Closas, S.J. Chanock, J. Lissowska, J.D. Figueroa, K. Czene, M. Eriksson, K. Humphreys, H. Darabi, M.J. Hooning, M. Kriege, J.M. Collée, M. Tilanus-Linthorst, J. Li, A. Jakubowska, J. Lubinski, K. Jaworska-Bieniek, K. Durda, H. Nevanlinna, T.A. Muranen, K. Aittomäki, C. Blomqvist, N. Bogdanova, T. Dörk, P. Hall, G. Chenevix-Trench, D.F. Easton, P.D.P. Pharoah, J.I. Arias-Perez, P. Zamora, J. Benítez, and R.L. Milne
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Summary:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium.
Item Description:Gesehen am 30.09.2020
Physical Description:Online Resource
ISSN:1532-1827
DOI:10.1038/bjc.2013.769