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Disentangling molecular mechanisms regulating sensitization of interferon alpha signal transduction

Abstract Tightly interlinked feedback regulators control the dynamics of intracellular responses elicited by the activation of signal transduction pathways. Interferon alpha (IFNα) orchestrates antiviral responses in hepatocytes, yet mechanisms that define pathway sensitization in response to presti...

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Main Authors: Kok, Frédérique (Author) , Rosenblatt, Marcus (Author) , Teusel, Melissa (Author) , Nizharadze, Tamar (Author) , Gonçalves Magalhães, Vladimir (Author) , Dächert, Christopher (Author) , Maiwald, Tim (Author) , Vlasov, Artyom (Author) , Wäsch, Marvin (Author) , Tyufekchieva, Silvana (Author) , Hoffmann, Katrin (Author) , Damm, Georg (Author) , Seehofer, Daniel (Author) , Böttler, Tobias (Author) , Binder, Marco (Author) , Timmer, Jens (Author) , Schilling, Marcel (Author) , Klingmüller, Ursula (Author)
Format: Article (Journal)
Language:English
Published: 21 July 2020
In: Molecular systems biology
Year: 2020, Volume: 16, Issue: 7
ISSN:1744-4292
DOI:10.15252/msb.20198955
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.15252/msb.20198955
Verlag, lizenzpflichtig, Volltext: https://www.embopress.org/doi/full/10.15252/msb.20198955
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Author Notes:Frédérique Kok, Marcus Rosenblatt, Melissa Teusel, Tamar Nizharadze, Vladimir Gonçalves Magalhães, Christopher Dächert, Tim Maiwald, Artyom Vlasov, Marvin Wäsch, Silvana Tyufekchieva, Katrin Hoffmann, Georg Damm, Daniel Seehofer, Tobias Boettler, Marco Binder, Jens Timmer, Marcel Schilling & Ursula Klingmüller

MARC

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520 |a Abstract Tightly interlinked feedback regulators control the dynamics of intracellular responses elicited by the activation of signal transduction pathways. Interferon alpha (IFNα) orchestrates antiviral responses in hepatocytes, yet mechanisms that define pathway sensitization in response to prestimulation with different IFNα doses remained unresolved. We establish, based on quantitative measurements obtained for the hepatoma cell line Huh7.5, an ordinary differential equation model for IFNα signal transduction that comprises the feedback regulators STAT1, STAT2, IRF9, USP18, SOCS1, SOCS3, and IRF2. The model-based analysis shows that, mediated by the signaling proteins STAT2 and IRF9, prestimulation with a low IFNα dose hypersensitizes the pathway. In contrast, prestimulation with a high dose of IFNα leads to a dose-dependent desensitization, mediated by the negative regulators USP18 and SOCS1 that act at the receptor. The analysis of basal protein abundance in primary human hepatocytes reveals high heterogeneity in patient-specific amounts of STAT1, STAT2, IRF9, and USP18. The mathematical modeling approach shows that the basal amount of USP18 determines patient-specific pathway desensitization, while the abundance of STAT2 predicts the patient-specific IFNα signal response. 
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