Gene expression profiling of colorectal tumors and normal Mucosa by microarrays meta-analysis using prediction analysis of microarray, artificial neural network, classification, and regression trees
Background. Microarray technology shows great potential but previous studies were limited by small number of samples in the colorectal cancer (CRC) research. The aims of this study are to investigate gene expression profile of CRCs by pooling cDNA microarrays using PAM, ANN, and decision trees (CART...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
19 May 2014
|
| In: |
Disease markers
|
| ISSN: | 1875-8630 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://www.hindawi.com/journals/dm/2014/634123/
|
| Verfasserangaben: | Chi-Ming Chu, Chung-Tay Yao, Yu-Tien Chang, Hsiu-Ling Chou, Yu-Ching Chou, Kang-Hua Chen, Harn-Jing Terng, Chi-Shuan Huang, Chia-Cheng Lee, Sui-Lun Su, Yao-Chi Liu, Fu-Gong Lin, Thomas Wetter, and Chi-Wen Chang |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1734292180 | ||
| 003 | DE-627 | ||
| 005 | 20230426162532.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201001s2014 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)1734292180 | ||
| 035 | |a (DE-599)KXP1734292180 | ||
| 035 | |a (OCoLC)1341368209 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Chu, Chi-Ming |d 1970- |e VerfasserIn |0 (DE-588)129275611 |0 (DE-627)39238387X |0 (DE-576)297574396 |4 aut | |
| 245 | 1 | 0 | |a Gene expression profiling of colorectal tumors and normal Mucosa by microarrays meta-analysis using prediction analysis of microarray, artificial neural network, classification, and regression trees |c Chi-Ming Chu, Chung-Tay Yao, Yu-Tien Chang, Hsiu-Ling Chou, Yu-Ching Chou, Kang-Hua Chen, Harn-Jing Terng, Chi-Shuan Huang, Chia-Cheng Lee, Sui-Lun Su, Yao-Chi Liu, Fu-Gong Lin, Thomas Wetter, and Chi-Wen Chang |
| 264 | 1 | |c 19 May 2014 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 01.10.2020 | ||
| 520 | |a Background. Microarray technology shows great potential but previous studies were limited by small number of samples in the colorectal cancer (CRC) research. The aims of this study are to investigate gene expression profile of CRCs by pooling cDNA microarrays using PAM, ANN, and decision trees (CART and C5.0). Methods. Pooled 16 datasets contained 88 normal mucosal tissues and 1186 CRCs. PAM was performed to identify significant expressed genes in CRCs and models of PAM, ANN, CART, and C5.0 were constructed for screening candidate genes via ranking gene order of significances. Results. The first screening identified 55 genes. The test accuracy of each model was over 0.97 averagely. Less than eight genes achieve excellent classification accuracy. Combining the results of four models, we found the top eight differential genes in CRCs; suppressor genes, CA7, SPIB, GUCA2B, AQP8, IL6R and CWH43; oncogenes, SPP1 and TCN1. Genes of higher significances showed lower variation in rank ordering by different methods. Conclusion. We adopted a two-tier genetic screen, which not only reduced the number of candidate genes but also yielded good accuracy (nearly 100%). This method can be applied to future studies. Among the top eight genes, CA7, TCN1, and CWH43 have not been reported to be related to CRC. | ||
| 700 | 1 | |a Yao, Chung-Tay |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chang, Yu-Tien |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chou, Hsiu-Ling |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chou, Yu-Ching |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chen, Kang-Hua |e VerfasserIn |4 aut | |
| 700 | 1 | |a Terng, Harn-Jing |e VerfasserIn |4 aut | |
| 700 | 1 | |a Huang, Chi-Shuan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lee, Chia-Cheng |e VerfasserIn |4 aut | |
| 700 | 1 | |a Su, Sui-Lun |e VerfasserIn |4 aut | |
| 700 | 1 | |a Liu, Yao-Chi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lin, Fu-Gong |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wetter, Thomas |d 1953- |e VerfasserIn |0 (DE-588)141236124 |0 (DE-627)703920774 |0 (DE-576)322863252 |4 aut | |
| 700 | 1 | |a Chang, Chi-Wen |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Disease markers |d [Hoboken, NJ] : Wiley, 1993 |g (2014) Artikel-Nummer 634123, 11 Seiten |h Online-Ressource |w (DE-627)324960247 |w (DE-600)2033253-1 |w (DE-576)273880144 |x 1875-8630 |7 nnas |a Gene expression profiling of colorectal tumors and normal Mucosa by microarrays meta-analysis using prediction analysis of microarray, artificial neural network, classification, and regression trees |
| 773 | 1 | 8 | |g year:2014 |a Gene expression profiling of colorectal tumors and normal Mucosa by microarrays meta-analysis using prediction analysis of microarray, artificial neural network, classification, and regression trees |
| 856 | 4 | 0 | |u https://www.hindawi.com/journals/dm/2014/634123/ |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20201001 | ||
| 993 | |a Article | ||
| 994 | |a 2014 | ||
| 998 | |g 141236124 |a Wetter, Thomas |m 141236124:Wetter, Thomas |d 910000 |d 999701 |e 910000PW141236124 |e 999701PW141236124 |k 0/910000/ |k 1/910000/999701/ |p 13 | ||
| 999 | |a KXP-PPN1734292180 |e 3764584718 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["2033253-1"],"eki":["324960247"],"doi":["10.1155/4242"],"issn":["1875-8630"]},"origin":[{"publisher":"Wiley ; IOS Press ; Hindawi","dateIssuedKey":"2024","dateIssuedDisp":"2024-","publisherPlace":"[Hoboken, NJ] ; Amsterdam ; New York, NY [u.a.]"}],"recId":"324960247","language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 19.02.2025","Fortsetzung der Druck-Ausgabe"],"disp":"Gene expression profiling of colorectal tumors and normal Mucosa by microarrays meta-analysis using prediction analysis of microarray, artificial neural network, classification, and regression treesDisease markers","part":{"year":"2014","issue":"11 Seiten","volume":"(2014) Artikel-Nummer 634123","text":"(2014) Artikel-Nummer 634123, 11 Seiten"},"pubHistory":["11.1993 [?]-35.2013 ; 2014-"],"title":[{"title_sort":"Disease markers","title":"Disease markers"}]}],"language":["eng"],"recId":"1734292180","type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 01.10.2020"],"name":{"displayForm":["Chi-Ming Chu, Chung-Tay Yao, Yu-Tien Chang, Hsiu-Ling Chou, Yu-Ching Chou, Kang-Hua Chen, Harn-Jing Terng, Chi-Shuan Huang, Chia-Cheng Lee, Sui-Lun Su, Yao-Chi Liu, Fu-Gong Lin, Thomas Wetter, and Chi-Wen Chang"]},"person":[{"role":"aut","roleDisplay":"VerfasserIn","display":"Chu, Chi-Ming","given":"Chi-Ming","family":"Chu"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Yao, Chung-Tay","given":"Chung-Tay","family":"Yao"},{"role":"aut","display":"Chang, Yu-Tien","roleDisplay":"VerfasserIn","given":"Yu-Tien","family":"Chang"},{"roleDisplay":"VerfasserIn","display":"Chou, Hsiu-Ling","role":"aut","family":"Chou","given":"Hsiu-Ling"},{"display":"Chou, Yu-Ching","roleDisplay":"VerfasserIn","role":"aut","family":"Chou","given":"Yu-Ching"},{"display":"Chen, Kang-Hua","roleDisplay":"VerfasserIn","role":"aut","family":"Chen","given":"Kang-Hua"},{"given":"Harn-Jing","family":"Terng","role":"aut","display":"Terng, Harn-Jing","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Huang, Chi-Shuan","given":"Chi-Shuan","family":"Huang"},{"given":"Chia-Cheng","family":"Lee","role":"aut","display":"Lee, Chia-Cheng","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Su, Sui-Lun","roleDisplay":"VerfasserIn","given":"Sui-Lun","family":"Su"},{"family":"Liu","given":"Yao-Chi","roleDisplay":"VerfasserIn","display":"Liu, Yao-Chi","role":"aut"},{"family":"Lin","given":"Fu-Gong","display":"Lin, Fu-Gong","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Wetter, Thomas","roleDisplay":"VerfasserIn","role":"aut","family":"Wetter","given":"Thomas"},{"given":"Chi-Wen","family":"Chang","role":"aut","display":"Chang, Chi-Wen","roleDisplay":"VerfasserIn"}],"id":{"eki":["1734292180"]},"origin":[{"dateIssuedDisp":"19 May 2014","dateIssuedKey":"2014"}],"title":[{"title":"Gene expression profiling of colorectal tumors and normal Mucosa by microarrays meta-analysis using prediction analysis of microarray, artificial neural network, classification, and regression trees","title_sort":"Gene expression profiling of colorectal tumors and normal Mucosa by microarrays meta-analysis using prediction analysis of microarray, artificial neural network, classification, and regression trees"}]} | ||
| SRT | |a CHUCHIMINGGENEEXPRES1920 | ||