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Promoter region single nucleotide polymorphism of siglec-8 gene associates with susceptibility to allergic asthma

Aim: Siglec-8 is exclusively expressed on mast cells, eosinophils and basophils. Possible association of six siglec-8 single nucleotide polymorphisms (SNPs) with susceptibility to allergic asthma in the Azeri population of Iran was investigated in this study. Materials & methods: A total of 194...

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Main Authors: Sajay-Asbaghi, Mohammad (Author) , Sadeghi-shabestrai, Mahnaz (Author) , Monfaredan, Amir (Author) , Seyfizadeh, Narges (Author) , Razavi, Alireza (Author) , Kazemi, Tohid (Author)
Format: Article (Journal)
Language:English
Published: 20 Feb 2020
In: Personalized medicine
Year: 2020, Volume: 17, Issue: 3, Pages: 195-201
ISSN:1744-828X
DOI:10.2217/pme-2018-0080
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2217/pme-2018-0080
Verlag, lizenzpflichtig, Volltext: https://www.futuremedicine.com/doi/10.2217/pme-2018-0080
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Author Notes:Mohammad Sajay-asbaghi, Mahnaz Sadeghi-shabestrai, Amir Monfaredan, Narges Seyfizadeh, Alireza Razavi & Tohid Kazemi

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520 |a Aim: Siglec-8 is exclusively expressed on mast cells, eosinophils and basophils. Possible association of six siglec-8 single nucleotide polymorphisms (SNPs) with susceptibility to allergic asthma in the Azeri population of Iran was investigated in this study. Materials & methods: A total of 194 patients and 190 normal subjects were enrolled. PCR single strand conformation polymorphism (PCR-SSCP) was used to determine the genotypes of the studied SNPs. Results: The rs36498 showed significant association with allergic asthma (odds ratio [OR]: 0.65; p = 0.022) and the T allele was found as a protective allele (OR: 0.61; p = 0.008). Also, eosinophil count in the CC genotype was significantly higher than that in the other genotypes (p = 0.026). Conclusion: The rs36498 is thought to influence the expression level of siglec-8. Siglec-8 could be a potential therapeutic target for allergic asthma. 
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