A meta-analysis on resting state high-frequency heart rate variability in bulimia nervosa

Objective: Autonomic nervous system function is altered in eating disorders. We aimed to quantify differences in resting state vagal activity, indexed by high-frequency heart rate variability comparing patients with bulimia nervosa (BN) and healthy controls. Methods A systematic search of the litera...

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Hauptverfasser: Peschel, Stephanie (VerfasserIn) , Feeling, Nicole R. (VerfasserIn) , Vögele, Claus (VerfasserIn) , Kaess, Michael (VerfasserIn) , Thayer, Julian F. (VerfasserIn) , Koenig, Julian (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 31 May 2016
In: European eating disorders review
Year: 2016, Jahrgang: 24, Heft: 5, Pages: 355-365
ISSN:1099-0968
DOI:10.1002/erv.2454
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/erv.2454
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/erv.2454
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Verfasserangaben:Stephanie K. V. Peschel, Nicole R. Feeling, Claus Vögele, Michael Kaess, Julian F. Thayer & Julian Koenig

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520 |a Objective: Autonomic nervous system function is altered in eating disorders. We aimed to quantify differences in resting state vagal activity, indexed by high-frequency heart rate variability comparing patients with bulimia nervosa (BN) and healthy controls. Methods A systematic search of the literature to identify studies eligible for inclusion and meta-analytical methods were applied. Meta-regression was used to identify potential covariates. Results: Eight studies reporting measures of resting high-frequency heart rate variability in individuals with BN (n = 137) and controls (n = 190) were included. Random-effects meta-analysis revealed a sizeable main effect (Z = 2.22, p = .03; Hedge's g = 0.52, 95% CI [0.06;0.98]) indicating higher resting state vagal activity in individuals with BN. Meta-regression showed that body mass index and medication intake are significant covariates. Discussion: Findings suggest higher vagal activity in BN at rest, particularly in unmedicated samples with lower body mass index. Potential mechanisms underlying these findings and implications for routine clinical care are discussed. 
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