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Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants

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Excitotoxicity induced by NMDA receptors (NMDARs) is thought to be intimately linked to high intracellular calcium load. Unexpectedly, NMDAR-mediated toxicity can be eliminated without affecting NMDAR-induced calcium signals. Instead, excitotoxicity requires physical coupling of NMDARs to TRPM4. Thi...

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Main Authors: Yan, Jing (Author) , Bengtson, C. Peter (Author) , Buchthal, Bettina (Author) , Hertle, Anna M. (Author) , Bading, Hilmar (Author)
Format: Article (Journal)
Language:English
Published: 09 Oct 2020
In: Science
Year: 2020, Volume: 370, Issue: 6513
ISSN:1095-9203
DOI:10.1126/science.aay3302
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1126/science.aay3302
Verlag, lizenzpflichtig, Volltext: https://science.sciencemag.org/content/370/6513/eaay3302
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Author Notes:Jing Yan, C. Peter Bengtson, Bettina Buchthal, Anna M. Hagenston, Hilmar Bading
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Coupling of NMDA receptors and TRPM4 guides discovery of unconventional neuroprotectants by Yan, Jing (Author) , Bengtson, C. Peter (Author) , Buchthal, Bettina (Author) , Hertle, Anna M. (Author) , Bading, Hilmar (Author) ,


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