Mitochondria tether protein trash to rejuvenate cellular environments
Protein damage segregates asymmetrically in dividing yeast cells, rejuvenating daughters at the expense of mother cells. Zhou et al. now show that newly synthesized proteins are particularly prone to aggregation and describe a mechanism that tethers aggregated proteins to mitochondria. This associat...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
23 October 2014
|
| In: |
Cell
Year: 2014, Volume: 159, Issue: 3, Pages: 471-472 |
| ISSN: | 1097-4172 |
| DOI: | 10.1016/j.cell.2014.10.007 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cell.2014.10.007 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S009286741401294X 
|
| Author Notes: | Axel Mogk, Bernd Bukau |
| Summary: | Protein damage segregates asymmetrically in dividing yeast cells, rejuvenating daughters at the expense of mother cells. Zhou et al. now show that newly synthesized proteins are particularly prone to aggregation and describe a mechanism that tethers aggregated proteins to mitochondria. This association constrains aggregate mobility, effectively retaining and sorting toxic aggregates away from younger cells. |
|---|---|
| Item Description: | Gesehen am 09.10.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1097-4172 |
| DOI: | 10.1016/j.cell.2014.10.007 |