Synthesis and lipophilicity evaluation of some novel indole-containing pseudopeptides
An efficient synthesis of indole-containing pseudopeptides via an Ugi four-component reaction among indolecarboxylic acids, aromatic aldehydes, primary amines, and isocyanides in methanol is described. The lipophilicity of the synthesized compounds was determined using the n-octanol/PBS shake-flask...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2014
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| In: |
Monatshefte für Chemie
Year: 2013, Jahrgang: 145, Heft: 2, Pages: 349-356 |
| ISSN: | 1434-4475 |
| DOI: | 10.1007/s00706-013-1098-0 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00706-013-1098-0 Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007%2Fs00706-013-1098-0 |
| Verfasserangaben: | Nahid S. Alavijeh · Sorour Ramezanpour · Mohammad S. Alavijeh · Saeed Balalaie · Frank Rominger · Anil Misra · Hamid Reza Bijanzadeh |
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| 520 | |a An efficient synthesis of indole-containing pseudopeptides via an Ugi four-component reaction among indolecarboxylic acids, aromatic aldehydes, primary amines, and isocyanides in methanol is described. The lipophilicity of the synthesized compounds was determined using the n-octanol/PBS shake-flask procedure. The lipophilicity studies showed that most of the compounds possess the optimal range of lipophilicity for oral absorption, cell membrane penetration, and blood-brain barrier permeation. | ||
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