A framework for modelling gene regulation which accommodates non-equilibrium mechanisms
Gene regulation has, for the most part, been quantitatively analysed by assuming that regulatory mechanisms operate at thermodynamic equilibrium. This formalism was originally developed to analyse the binding and unbinding of transcription factors from naked DNA in eubacteria. Although widely used,...
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| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
05 December 2014
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| In: |
BMC biology
Year: 2014, Volume: 12 |
| ISSN: | 1741-7007 |
| DOI: | 10.1186/s12915-014-0102-4 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12915-014-0102-4
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| Author Notes: | Tobias Ahsendorf, Felix Wong, Roland Eils and Jeremy Gunawardena |
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| 520 | |a Gene regulation has, for the most part, been quantitatively analysed by assuming that regulatory mechanisms operate at thermodynamic equilibrium. This formalism was originally developed to analyse the binding and unbinding of transcription factors from naked DNA in eubacteria. Although widely used, it has made it difficult to understand the role of energy-dissipating, epigenetic mechanisms, such as DNA methylation, nucleosome remodelling and post-translational modification of histones and co-regulators, which act together with transcription factors to regulate gene expression in eukaryotes. | ||
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