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Strategies for improving the solubility and metabolic stability of griseofulvin analogues

We report two types of modifications to the natural product griseofulvin as strategies to improve solubility and metabolic stability: the conversion of aryl methyl ethers into aryl difluoromethyl ethers at metabolic hotspots and the conversion of the C-ring ketone into polar oximes. The syntheses of...

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Main Authors: Petersen, Asger B. (Author) , Konotop, Gleb (Author) , Hanafiah, Nur Hafzan Md (Author) , Hammershøj, P. (Author) , Raab, Marc-Steffen (Author) , Krämer, Alwin (Author) , Clausen, M. H. (Author)
Format: Article (Journal)
Language:English
Published: 28 March 2016
In: European journal of medicinal chemistry
Year: 2016, Volume: 116, Pages: 210-215
ISSN:1768-3254
DOI:10.1016/j.ejmech.2016.03.071
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejmech.2016.03.071
Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0223523416302537
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Author Notes:A. B. Petersen, G. Konotop, N. H. M. Hanafiah, P. Hammershøj, M. S. Raab, A. Krämer, M. H. Clausen

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