Prognostic value of high-sensitivity versus conventional cardiac troponin T assays among patients with type 2 diabetes mellitus undergoing maintenance hemodialysis
Background - Mortality is high among patients undergoing hemodialysis for whom cardiac troponin concentration is a strong predictor of outcome. Modern troponin assays allow measurement of very low concentrations. - Study Design - Using data from a randomized controlled trial, a cohort analysis to ev...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
January 6, 2018
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| In: |
American journal of kidney diseases
Year: 2018, Jahrgang: 71, Heft: 6, Pages: 822-830 |
| ISSN: | 1523-6838 |
| DOI: | 10.1053/j.ajkd.2017.10.016 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1053/j.ajkd.2017.10.016 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S0272638617310740 
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| Verfasserangaben: | Till Keller, Christoph Wanner, Vera Krane, Daniel Kraus, Bernd Genser, Hubert Scharnagl, Winfried März, and Christiane Drechsler |
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| 245 | 1 | 0 | |a Prognostic value of high-sensitivity versus conventional cardiac troponin T assays among patients with type 2 diabetes mellitus undergoing maintenance hemodialysis |c Till Keller, Christoph Wanner, Vera Krane, Daniel Kraus, Bernd Genser, Hubert Scharnagl, Winfried März, and Christiane Drechsler |
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| 520 | |a Background - Mortality is high among patients undergoing hemodialysis for whom cardiac troponin concentration is a strong predictor of outcome. Modern troponin assays allow measurement of very low concentrations. - Study Design - Using data from a randomized controlled trial, a cohort analysis to evaluate the prognostic value of very low cardiac troponin T (TnT) concentrations. - Setting & Participants - 1,255 patients with end-stage renal disease and type 2 diabetes mellitus undergoing maintenance hemodialysis from the German Diabetes and Dialysis Study (4D) who had a median follow-up of 4 years. - Index Test, Reference Test, and Outcome - Cardiac TnT was measured using a high-sensitivity assay (hs-TnT) and a conventional assay (conventional TnT) in a subpopulation (n=1,034) with valid measurements for both assays. Outcome measures were all-cause mortality and a composite cardiovascular end point including cardiac death, myocardial infarction, or stroke. - Results - Among the 1,034 study participants, 505 died and 377 had a cardiovascular event. Both hs-TnT and conventional TnT concentrations were associated with mortality and cardiovascular events in models adjusted for cardiovascular risk factors and dialysis-associated variables. 455 (44%) patients with very low TnT concentrations (hs-TNT < 50ng/L) would have been classified as normal by the conventional TnT assay. Among these patients, hs-TnT concentrations were also associated with mortality. - Limitations - The study of patients with type 2 diabetes may limit generalizability. These findings have not been externally validated. - Conclusions - In patients with type 2 diabetes mellitus receiving hemodialysis, cardiac TnT is associated with long-term mortality and cardiovascular outcomes. Concentrations of TnT not measurable with acceptable precision using a conventional TnT assay were associated with a poor prognosis when measured using a high-sensitivity assay. | ||
| 650 | 4 | |a assay sensitivity | |
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| 650 | 4 | |a cardiac death | |
| 650 | 4 | |a Cardiac troponin T (TnT) | |
| 650 | 4 | |a cardiovascular disease | |
| 650 | 4 | |a end-stage renal disease (ESRD) | |
| 650 | 4 | |a haemodialysis | |
| 650 | 4 | |a hemodialysis | |
| 650 | 4 | |a high-sensitivity | |
| 650 | 4 | |a kidney clearance | |
| 650 | 4 | |a myocardial infarction (MI) | |
| 650 | 4 | |a prognosis | |
| 650 | 4 | |a stroke | |
| 650 | 4 | |a survival | |
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