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The helix-loop-helix protein Id1 controls stem cell proliferation during regenerative neurogenesis in the adult zebrafish telencephalon

The teleost brain has the remarkable ability to generate new neurons and to repair injuries during adult life stages. Maintaining life-long neurogenesis requires careful management of neural stem cell pools. In a genome-wide expression screen for transcription regulators, the id1 gene, encoding a ne...

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Bibliographische Detailangaben
Hauptverfasser: Rodríguez Viales, Rebecca (VerfasserIn) , Diotel, Nicolas (VerfasserIn) , Ferg, Marco (VerfasserIn) , Armant, Olivier (VerfasserIn) , Eich, Julia (VerfasserIn) , Alunni, Alessandro (VerfasserIn) , März, Martin (VerfasserIn) , Bally-Cuif, Laure (VerfasserIn) , Rastegar, Sepand (VerfasserIn) , Strähle, Uwe (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2015
In: Stem cells
Year: 2014, Jahrgang: 33, Heft: 3, Pages: 892-903
ISSN:1549-4918
DOI:10.1002/stem.1883
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1002/stem.1883
Verlag, lizenzpflichtig, Volltext: https://stemcellsjournals.onlinelibrary.wiley.com/doi/abs/10.1002/stem.1883
Volltext
Verfasserangaben:Rebecca Rodriguez Viales, Nicolas Diotel, Marco Ferg, Olivier Armant, Julia Eich, Alessandro Alunni, Martin März, Laure Bally-Cuif, Sepand Rastegar, Uwe Strähle
Beschreibung
Zusammenfassung:The teleost brain has the remarkable ability to generate new neurons and to repair injuries during adult life stages. Maintaining life-long neurogenesis requires careful management of neural stem cell pools. In a genome-wide expression screen for transcription regulators, the id1 gene, encoding a negative regulator of E-proteins, was found to be upregulated in response to injury. id1 expression was mapped to quiescent type I neural stem cells in the adult telencephalic stem cell niche. Gain and loss of id1 function in vivo demonstrated that Id1 promotes stem cell quiescence. The increased id1 expression observed in neural stem cells in response to injury appeared independent of inflammatory signals, suggesting multiple antagonistic pathways in the regulation of reactive neurogenesis. Together, we propose that Id1 acts to maintain the neural stem cell pool by counteracting neurogenesis-promoting signals. Stem Cells 2015;33:892-903
Beschreibung:published online November 6, 2014
Gesehen am 13.10.2020
Beschreibung:Online Resource
ISSN:1549-4918
DOI:10.1002/stem.1883

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