Microdomain calcium fluctuations as a colored noise process
Calcium ions play a key role in subcellular signaling as localized transients of the intracellular calcium concentration modify the activity of ion channels, enzymes and transcription factors, among others. The intracellular calcium concentration is inherently noisy, as diffusion, the transient bind...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
03 November 2014
|
| In: |
Frontiers in genetics
Year: 2014, Volume: 5 |
| ISSN: | 1664-8021 |
| DOI: | 10.3389/fgene.2014.00376 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.3389/fgene.2014.00376 Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/articles/10.3389/fgene.2014.00376/full 
|
| Author Notes: | Frederic von Wegner, Nicolas Wieder and Rainer H.A. Fink |
| Summary: | Calcium ions play a key role in subcellular signaling as localized transients of the intracellular calcium concentration modify the activity of ion channels, enzymes and transcription factors, among others. The intracellular calcium concentration is inherently noisy, as diffusion, the transient binding to and dissociation from buffer molecules and stochastically gating calcium channels contribute to the fluctuations of the local copy number of Ca2+ ions. We study the properties of the fluctuating calcium concentration in sub-femtoliter volumes using an exact stochastic simulation algorithm and approximations to the exact stochastic solution. |
|---|---|
| Item Description: | Gesehen am 14.10.2020 |
| Physical Description: | Online Resource |
| ISSN: | 1664-8021 |
| DOI: | 10.3389/fgene.2014.00376 |