Genetic variation in vitamin D receptor gene (Fok1:rs2228570) is associated with risk of coronary artery disease
Objective: The Fok1 polymorphism (rs2228570) in vitamin D receptor gene appears to be the only polymorphism influencing size of translated protein. Investigations into its association with coronary artery disease (CAD) are sparse.Methods: Male patients (n = 98) with verified CAD were recruited along...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2016
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| In: |
Biomarkers
Year: 2015, Jahrgang: 21, Heft: 1, Pages: 68-72 |
| ISSN: | 1366-5804 |
| DOI: | 10.3109/1354750X.2015.1118535 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3109/1354750X.2015.1118535
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| Verfasserangaben: | Mohamed A. Abu el Maaty, Sally I. Hassanein, Mohamed Z. Gad |
| Zusammenfassung: | Objective: The Fok1 polymorphism (rs2228570) in vitamin D receptor gene appears to be the only polymorphism influencing size of translated protein. Investigations into its association with coronary artery disease (CAD) are sparse.Methods: Male patients (n = 98) with verified CAD were recruited alongside age- and sex-matched controls (n = 55). Genotyping was performed by PCR-RFLP and plasma 25-Hydroxyvitamin D levels were assessed by HPLC-UV.Results: The C-variant (mutant) was predominantly expressed in patients compared to controls (68.9% versus 55.5%; p = 0.025). The observed genotypes were not associated with 25-Hydroxyvitamin D levels.Conclusion: This study presents Fok1 polymorphism as a potential genetic marker for CAD. |
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| Beschreibung: | Published online: 08 Dec 2015 Gesehen am 14.10.2020 |
| Beschreibung: | Online Resource |
| ISSN: | 1366-5804 |
| DOI: | 10.3109/1354750X.2015.1118535 |