Shared and cell type-specific adaptation strategies of Gag and Env yield high titer bovine foamy virus variants
During in vitro selection and evolution screens to adapt the tightly cell-associated bovine foamy virus BFV to high titer cell-free transmission, common, cell-type specific and concurrent adaptive changes in Gag and Env, the major players of foamy virus particle assembly and release, were detected....
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
13 March 2020
|
| In: |
Infection, genetics and evolution
Year: 2020, Jahrgang: 82 |
| ISSN: | 1567-7257 |
| DOI: | 10.1016/j.meegid.2020.104287 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.meegid.2020.104287 Verlag, lizenzpflichtig, Volltext: http://www.sciencedirect.com/science/article/pii/S1567134820301180 
|
| Verfasserangaben: | Qiuying Bao, Agnes Hotz-Wagenblatt, Matthew J. Betts, Michaela Hipp, Annette Hugo, Georgios Pougialis, Janet Lei-Rossmann, Martin Löchelt |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1735654337 | ||
| 003 | DE-627 | ||
| 005 | 20220818225737.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201015s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.meegid.2020.104287 |2 doi | |
| 035 | |a (DE-627)1735654337 | ||
| 035 | |a (DE-599)KXP1735654337 | ||
| 035 | |a (OCoLC)1341371330 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Bao, Qiu Ying |e VerfasserIn |0 (DE-588)1076288103 |0 (DE-627)834615509 |0 (DE-576)445159596 |4 aut | |
| 245 | 1 | 0 | |a Shared and cell type-specific adaptation strategies of Gag and Env yield high titer bovine foamy virus variants |c Qiuying Bao, Agnes Hotz-Wagenblatt, Matthew J. Betts, Michaela Hipp, Annette Hugo, Georgios Pougialis, Janet Lei-Rossmann, Martin Löchelt |
| 264 | 1 | |c 13 March 2020 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 15.10.2020 | ||
| 520 | |a During in vitro selection and evolution screens to adapt the tightly cell-associated bovine foamy virus BFV to high titer cell-free transmission, common, cell-type specific and concurrent adaptive changes in Gag and Env, the major players of foamy virus particle assembly and release, were detected. Upon early establishment of cell type-independent pioneering mutations in Env and, subsequently in Gag, a diverse virus pool emerged that was characterized by the occurrence of shared and additional cell type-specific exchanges. At late passages and saturated titers, remarkably homogeneous virus populations characterized by functionally important mutations developed which may be partly due to stochastic evolutionary events that occurred earlier during adaptation. Reverse genetics showed that defined mutations were functionally important for high titer cell-free transmission. | ||
| 650 | 4 | |a Cell-free transmission | |
| 650 | 4 | |a Co-evolution and co-adaptation of genes | |
| 650 | 4 | |a Foamy virus | |
| 650 | 4 | |a Pioneering mutation | |
| 650 | 4 | |a Stochastic evolution | |
| 650 | 4 | |a Virus evolution | |
| 700 | 1 | |a Hotz-Wagenblatt, Agnes |e VerfasserIn |0 (DE-588)1163289310 |0 (DE-627)1027495982 |0 (DE-576)507876806 |4 aut | |
| 700 | 1 | |a Betts, Matthew J. |e VerfasserIn |0 (DE-588)1050283740 |0 (DE-627)78378127X |0 (DE-576)404498930 |4 aut | |
| 700 | 1 | |a Hipp, Michaela |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hugo, Annette |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pougialis, Georgios |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lei-Rossmann, Janet |e VerfasserIn |4 aut | |
| 700 | 1 | |a Löchelt, Martin |e VerfasserIn |0 (DE-588)1106411617 |0 (DE-627)863134173 |0 (DE-576)165786078 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Infection, genetics and evolution |d Amsterdam [u.a.] : Elsevier Science, 2001 |g 82(2020) Artikel-Nummer 104287, 6 Seiten |h Online-Ressource |w (DE-627)334374952 |w (DE-600)2057622-5 |w (DE-576)264629175 |x 1567-7257 |7 nnas |a Shared and cell type-specific adaptation strategies of Gag and Env yield high titer bovine foamy virus variants |
| 773 | 1 | 8 | |g volume:82 |g year:2020 |g extent:6 |a Shared and cell type-specific adaptation strategies of Gag and Env yield high titer bovine foamy virus variants |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.meegid.2020.104287 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S1567134820301180 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20201015 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 1106411617 |a Löchelt, Martin |m 1106411617:Löchelt, Martin |d 50000 |e 50000PL1106411617 |k 0/50000/ |p 8 |y j | ||
| 998 | |g 1050283740 |a Betts, Matthew J. |m 1050283740:Betts, Matthew J. |p 3 | ||
| 998 | |g 1163289310 |a Hotz-Wagenblatt, Agnes |m 1163289310:Hotz-Wagenblatt, Agnes |d 140000 |e 140000PH1163289310 |k 0/140000/ |p 2 | ||
| 999 | |a KXP-PPN1735654337 |e 3780127954 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"6 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"Amsterdam [u.a.]","publisher":"Elsevier Science","dateIssuedKey":"2001","dateIssuedDisp":"2001-"}],"id":{"zdb":["2057622-5"],"eki":["334374952"],"issn":["1567-7257"]},"pubHistory":["1.2001 -"],"part":{"extent":"6","volume":"82","text":"82(2020) Artikel-Nummer 104287, 6 Seiten","year":"2020"},"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 13.02.20"],"disp":"Shared and cell type-specific adaptation strategies of Gag and Env yield high titer bovine foamy virus variantsInfection, genetics and evolution","language":["eng"],"recId":"334374952","title":[{"subtitle":"journal of molecular epidemiology and evolutionary genetics and infectious diseases (MEEGID)","title":"Infection, genetics and evolution","title_sort":"Infection, genetics and evolution"}]}],"name":{"displayForm":["Qiuying Bao, Agnes Hotz-Wagenblatt, Matthew J. Betts, Michaela Hipp, Annette Hugo, Georgios Pougialis, Janet Lei-Rossmann, Martin Löchelt"]},"origin":[{"dateIssuedDisp":"13 March 2020","dateIssuedKey":"2020"}],"id":{"doi":["10.1016/j.meegid.2020.104287"],"eki":["1735654337"]},"note":["Gesehen am 15.10.2020"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"1735654337","language":["eng"],"person":[{"display":"Bao, Qiu Ying","roleDisplay":"VerfasserIn","role":"aut","family":"Bao","given":"Qiu Ying"},{"given":"Agnes","family":"Hotz-Wagenblatt","role":"aut","roleDisplay":"VerfasserIn","display":"Hotz-Wagenblatt, Agnes"},{"family":"Betts","given":"Matthew J.","roleDisplay":"VerfasserIn","display":"Betts, Matthew J.","role":"aut"},{"family":"Hipp","given":"Michaela","display":"Hipp, Michaela","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Hugo","given":"Annette","display":"Hugo, Annette","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","display":"Pougialis, Georgios","roleDisplay":"VerfasserIn","given":"Georgios","family":"Pougialis"},{"role":"aut","display":"Lei-Rossmann, Janet","roleDisplay":"VerfasserIn","given":"Janet","family":"Lei-Rossmann"},{"given":"Martin","family":"Löchelt","role":"aut","roleDisplay":"VerfasserIn","display":"Löchelt, Martin"}],"title":[{"title":"Shared and cell type-specific adaptation strategies of Gag and Env yield high titer bovine foamy virus variants","title_sort":"Shared and cell type-specific adaptation strategies of Gag and Env yield high titer bovine foamy virus variants"}]} | ||
| SRT | |a BAOQIUYINGSHAREDANDC1320 | ||