5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion
Abstract Nonsense-mediated RNA decay (NMD) is an RNA-based quality control mechanism that eliminates transcripts bearing premature translation termination codons (PTC). Approximately, one-third of all inherited disorders and some forms of cancer are caused by nonsense or frame shift mutations that i...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 October 2014
|
| In: |
EMBO molecular medicine
Year: 2014, Jahrgang: 6, Heft: 12, Pages: 1593-1609 |
| ISSN: | 1757-4684 |
| DOI: | 10.15252/emmm.201404461 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.15252/emmm.201404461 Verlag, lizenzpflichtig, Volltext: https://www.embopress.org/doi/full/10.15252/emmm.201404461 
|
| Verfasserangaben: | Madhuri Bhuvanagiri, Joe Lewis, Kerstin Putzker, Jonas P. Becker, Stefan Leicht, Jeroen Krijgsveld, Richa Batra, Brad Turnwald, Bogdan Jovanovic, Christian Hauer, Jana Sieber, Matthias W. Hentze & Andreas E. Kulozik |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1735673552 | ||
| 003 | DE-627 | ||
| 005 | 20220818225902.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 201015s2014 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.15252/emmm.201404461 |2 doi | |
| 035 | |a (DE-627)1735673552 | ||
| 035 | |a (DE-599)KXP1735673552 | ||
| 035 | |a (OCoLC)1341371417 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bhuvanagiri, Madhuri |e VerfasserIn |0 (DE-588)1209692651 |0 (DE-627)1697649963 |4 aut | |
| 245 | 1 | 0 | |a 5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion |c Madhuri Bhuvanagiri, Joe Lewis, Kerstin Putzker, Jonas P. Becker, Stefan Leicht, Jeroen Krijgsveld, Richa Batra, Brad Turnwald, Bogdan Jovanovic, Christian Hauer, Jana Sieber, Matthias W. Hentze & Andreas E. Kulozik |
| 246 | 3 | 3 | |a Five-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion |
| 264 | 1 | |c 15 October 2014 | |
| 300 | |a 17 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 15.10.2020 | ||
| 520 | |a Abstract Nonsense-mediated RNA decay (NMD) is an RNA-based quality control mechanism that eliminates transcripts bearing premature translation termination codons (PTC). Approximately, one-third of all inherited disorders and some forms of cancer are caused by nonsense or frame shift mutations that introduce PTCs, and NMD can modulate the clinical phenotype of these diseases. 5-azacytidine is an analogue of the naturally occurring pyrimidine nucleoside cytidine, which is approved for the treatment of myelodysplastic syndrome and myeloid leukemia. Here, we reveal that 5-azacytidine inhibits NMD in a dose-dependent fashion specifically upregulating the expression of both PTC-containing mutant and cellular NMD targets. Moreover, this activity of 5-azacytidine depends on the induction of MYC expression, thus providing a link between the effect of this drug and one of the key cellular pathways that are known to affect NMD activity. Furthermore, the effective concentration of 5-azacytidine in cells corresponds to drug levels used in patients, qualifying 5-azacytidine as a candidate drug that could potentially be repurposed for the treatment of Mendelian and acquired genetic diseases that are caused by PTC mutations. | ||
| 650 | 4 | |a 5-azacytidine | |
| 650 | 4 | |a MYC | |
| 650 | 4 | |a nonsense-mediated decay | |
| 650 | 4 | |a premature termination codons | |
| 700 | 1 | |a Becker, Jonas Philipp |d 1991- |e VerfasserIn |0 (DE-588)1050230825 |0 (DE-627)783666160 |0 (DE-576)404441149 |4 aut | |
| 700 | 1 | |a Krijgsveld, Jeroen |e VerfasserIn |0 (DE-588)1163292125 |0 (DE-627)1027502032 |0 (DE-576)507882474 |4 aut | |
| 700 | 1 | |a Jovanovic, Bogdan |e VerfasserIn |0 (DE-588)1159997101 |0 (DE-627)1023114887 |0 (DE-576)505443082 |4 aut | |
| 700 | 1 | |a Sieber, Jana |e VerfasserIn |0 (DE-588)1209691205 |0 (DE-627)1697647278 |4 aut | |
| 700 | 1 | |a Hentze, Matthias W. |d 1960- |e VerfasserIn |0 (DE-588)143450395 |0 (DE-627)646106775 |0 (DE-576)337135754 |4 aut | |
| 700 | 1 | |a Kulozik, Andreas |d 1959- |e VerfasserIn |0 (DE-588)1025736567 |0 (DE-627)723892032 |0 (DE-576)167091638 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a European Molecular Biology Organization |t EMBO molecular medicine |d [London] : Nature Publishing Group UK, 2009 |g 6(2014), 12, Seite 1593-1609 |h Online-Ressource |w (DE-627)594772761 |w (DE-600)2485479-7 |w (DE-576)305355961 |x 1757-4684 |7 nnas |
| 773 | 1 | 8 | |g volume:6 |g year:2014 |g number:12 |g pages:1593-1609 |g extent:17 |a 5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion |
| 856 | 4 | 0 | |u https://doi.org/10.15252/emmm.201404461 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.embopress.org/doi/full/10.15252/emmm.201404461 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20201015 | ||
| 993 | |a Article | ||
| 994 | |a 2014 | ||
| 998 | |g 1025736567 |a Kulozik, Andreas |m 1025736567:Kulozik, Andreas |d 910000 |d 910500 |e 910000PK1025736567 |e 910500PK1025736567 |k 0/910000/ |k 1/910000/910500/ |p 13 |y j | ||
| 998 | |g 143450395 |a Hentze, Matthias W. |m 143450395:Hentze, Matthias W. |d 50000 |e 50000PH143450395 |k 0/50000/ |p 12 | ||
| 998 | |g 1209691205 |a Sieber, Jana |m 1209691205:Sieber, Jana |d 910000 |d 910500 |e 910000PS1209691205 |e 910500PS1209691205 |k 0/910000/ |k 1/910000/910500/ |p 11 | ||
| 998 | |g 1159997101 |a Jovanovic, Bogdan |m 1159997101:Jovanovic, Bogdan |d 500000 |d 501036 |e 500000PJ1159997101 |e 501036PJ1159997101 |k 0/500000/ |k 1/500000/501036/ |p 9 | ||
| 998 | |g 1163292125 |a Krijgsveld, Jeroen |m 1163292125:Krijgsveld, Jeroen |d 50000 |e 50000PK1163292125 |k 0/50000/ |p 6 | ||
| 998 | |g 1050230825 |a Becker, Jonas Philipp |m 1050230825:Becker, Jonas Philipp |d 50000 |e 50000PB1050230825 |k 0/50000/ |p 4 | ||
| 999 | |a KXP-PPN1735673552 |e 3780214970 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"title":[{"title_sort":"5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion","title":"5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion"}],"note":["Gesehen am 15.10.2020"],"relHost":[{"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"dateIssuedDisp":"[2009]-","publisher":"Nature Publishing Group UK ; EMBO Press ; Wiley-VCH","publisherPlace":"[London] ; Heidelberg ; Weinheim"}],"recId":"594772761","physDesc":[{"extent":"Online-Ressource"}],"disp":"European Molecular Biology OrganizationEMBO molecular medicine","id":{"zdb":["2485479-7"],"issn":["1757-4684"],"doi":["10.1002/(ISSN)1757-4684"],"eki":["594772761"]},"note":["Gesehen am 5. November 2022","Fortsetzung der Druck-Ausgabe"],"corporate":[{"display":"European Molecular Biology Organization","role":"aut"}],"name":{"displayForm":["European Molecular Biology Organization (EMBO)"]},"pubHistory":["Vol. 1, No. 1 (Apr 1, 2009)-"],"title":[{"title_sort":"EMBO molecular medicine","title":"EMBO molecular medicine"}],"language":["eng"],"part":{"volume":"6","year":"2014","text":"6(2014), 12, Seite 1593-1609","issue":"12","extent":"17","pages":"1593-1609"}}],"physDesc":[{"extent":"17 S."}],"id":{"doi":["10.15252/emmm.201404461"],"eki":["1735673552"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"titleAlt":[{"title":"Five-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion"}],"origin":[{"dateIssuedKey":"2014","dateIssuedDisp":"15 October 2014"}],"recId":"1735673552","person":[{"family":"Bhuvanagiri","display":"Bhuvanagiri, Madhuri","role":"aut","given":"Madhuri"},{"family":"Becker","role":"aut","given":"Jonas Philipp","display":"Becker, Jonas Philipp"},{"family":"Krijgsveld","display":"Krijgsveld, Jeroen","role":"aut","given":"Jeroen"},{"display":"Jovanovic, Bogdan","given":"Bogdan","role":"aut","family":"Jovanovic"},{"display":"Sieber, Jana","role":"aut","given":"Jana","family":"Sieber"},{"display":"Hentze, Matthias W.","given":"Matthias W.","role":"aut","family":"Hentze"},{"family":"Kulozik","display":"Kulozik, Andreas","given":"Andreas","role":"aut"}],"name":{"displayForm":["Madhuri Bhuvanagiri, Joe Lewis, Kerstin Putzker, Jonas P. Becker, Stefan Leicht, Jeroen Krijgsveld, Richa Batra, Brad Turnwald, Bogdan Jovanovic, Christian Hauer, Jana Sieber, Matthias W. Hentze & Andreas E. Kulozik"]}} | ||
| SRT | |a BHUVANAGIR5AZACYTIDI1520 | ||